Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9920
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRomer, LM-
dc.contributor.authorHaverkamp, HC-
dc.contributor.authorLovering, AT-
dc.contributor.authorPegelow, DF-
dc.contributor.authorDempsey, JA-
dc.date.accessioned2015-01-23T13:35:35Z-
dc.date.available2006-02-
dc.date.available2015-01-23T13:35:35Z-
dc.date.issued2006-
dc.identifier.citationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, 290:2, pp. R365 - R375, 2006en_US
dc.identifier.issn0363-6119-
dc.identifier.urihttp://ajpregu.physiology.org/content/290/2/R365-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9920-
dc.description.abstractThe effect of exercise-induced arterial hypoxemia (EIAH) on quadriceps muscle fatigue was assessed in 11 male endurance-trained subjects [peak O2 uptake (V̇o2 peak) = 56.4 ± 2.8 ml·kg−1·min−1; mean ± SE]. Subjects exercised on a cycle ergometer at ≥90% V̇o2 peak to exhaustion (13.2 ± 0.8 min), during which time arterial O2 saturation (SaO2) fell from 97.7 ± 0.1% at rest to 91.9 ± 0.9% (range 84–94%) at end exercise, primarily because of changes in blood pH (7.183 ± 0.017) and body temperature (38.9 ± 0.2°C). On a separate occasion, subjects repeated the exercise, for the same duration and at the same power output as before, but breathed gas mixtures [inspired O2 fraction (FiO2) = 0.25–0.31] that prevented EIAH (SaO2 = 97–99%). Quadriceps muscle fatigue was assessed via supramaximal paired magnetic stimuli of the femoral nerve (1–100 Hz). Immediately after exercise at FiO2 0.21, the mean force response across 1–100 Hz decreased 33 ± 5% compared with only 15 ± 5% when EIAH was prevented (P < 0.05). In a subgroup of four less fit subjects, who showed minimal EIAH at FiO2 0.21 (SaO2 = 95.3 ± 0.7%), the decrease in evoked force was exacerbated by 35% (P < 0.05) in response to further desaturation induced via FiO2 0.17 (SaO2 = 87.8 ± 0.5%) for the same duration and intensity of exercise. We conclude that the arterial O2 desaturation that occurs in fit subjects during high-intensity exercise in normoxia (−6 ± 1% ΔSaO2 from rest) contributes significantly toward quadriceps muscle fatigue via a peripheral mechanism.en_US
dc.format.extentR365 - R375-
dc.format.extentR365 - R375-
dc.format.extentR365 - R375-
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.subjectMagnetic stimulationen_US
dc.subjectLow- and high-frequency fatigueen_US
dc.subjectQuadriceps twitch forceen_US
dc.subjectVoluntary activationen_US
dc.subjectPeripheral fatigueen_US
dc.subjectCentral fatigueen_US
dc.titleEffect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humansen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1152/ajpregu.00332.2005-
dc.relation.isPartOfAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
dc.relation.isPartOfAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
dc.relation.isPartOfAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
pubs.issue2-
pubs.issue2-
pubs.issue2-
pubs.volume290-
pubs.volume290-
pubs.volume290-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Sport
Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Notice.pdf42.55 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.