Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9916
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLovering, AT-
dc.contributor.authorRomer, LM-
dc.contributor.authorHaverkamp, HC-
dc.contributor.authorHokanson, JS-
dc.contributor.authorEldridge, MW-
dc.coverage.spatialUnited States-
dc.coverage.spatialUnited States-
dc.date.accessioned2015-01-23T11:58:47Z-
dc.date.available2007-
dc.date.available2015-01-23T11:58:47Z-
dc.date.issued2007-
dc.identifier.citationHigh Altitude Medicine and Biology, 8:1, pp. 62 - 67, 2007en_US
dc.identifier.issn1527-0297-
dc.identifier.urihttp://online.liebertpub.com/doi/abs/10.1089/ham.2006.0816-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9916-
dc.description.abstractA 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness.en_US
dc.format.extent62 - 67-
dc.format.extent62 - 67-
dc.languageeng-
dc.language.isoenen_US
dc.subjectAdulten_US
dc.subjectAltitude Sicknessen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectExerciseen_US
dc.subjectExercise Testen_US
dc.subjectExercise Toleranceen_US
dc.subjectForced Expiratory Flow Ratesen_US
dc.subjectForced Expiratory Volumeen_US
dc.subjectHumansen_US
dc.subjectInfant, Newbornen_US
dc.subjectMaleen_US
dc.subjectOxygen Consumptionen_US
dc.subjectPulmonary Edemaen_US
dc.subjectPulmonary Gas Exchangeen_US
dc.titleExcessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edemaen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1089/ham.2006.0816-
dc.relation.isPartOfHigh Altitude Medicine and Biology-
dc.relation.isPartOfHigh Altitude Medicine and Biology-
pubs.issue1-
pubs.issue1-
pubs.volume8-
pubs.volume8-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Sport
Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Fulltext.pdf204.41 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.