Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9911
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRomer, LM-
dc.contributor.authorHaverkamp, HC-
dc.contributor.authorAmann, M-
dc.contributor.authorLovering, AT-
dc.contributor.authorPegelow, DF-
dc.contributor.authorDempsey, JA-
dc.date.accessioned2015-01-22T14:22:18Z-
dc.date.available2007-
dc.date.available2015-01-22T14:22:18Z-
dc.date.issued2007-
dc.identifier.citationAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292:1, pp. R598 - R606, 2007en_US
dc.identifier.issn0363-6119-
dc.identifier.urihttp://ajpregu.physiology.org/content/292/1/R598-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9911-
dc.description.abstractEffect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292: R598–R606, 2007. First published September 7, 2006; doi:10.1152/ajpregu.00269.2006.—We hypothesized that severe hypoxia limits exercise performance via decreased contractility of limb locomotor muscles. Nine male subjects [mean SE maximum O2 uptake (V˙ O2 max) 56.5 2.7 ml kg 1 min 1] cycled at 90% V˙ O2 max to exhaustion in normoxia [NORM-EXH; inspired O2 fraction (FIO2) 0.21, arterial O2 saturation (SpO2) 93 1%] and hypoxia (HYPOX-EXH; FIO2 0.13, SpO2 76 1%). The subjects also exercised in normoxia for a time equal to that achieved in hypoxia (NORM-CTRL; SpO2 96 1%). Quadriceps twitch force, in response to supramaximal single (nonpotentiated and potentiated 1 Hz) and paired magnetic stimuli of the femoral nerve (10–100 Hz), was assessed pre- and at 2.5, 35, and 70 min postexercise. Hypoxia exacerbated exercise-induced peripheral fatigue, as evidenced by a greater decrease in potentiated twitch force in HYPOX-EXH vs. NORM-CTRL ( 39 4 vs. 24 3%, P 0.01). Time to exhaustion was reduced by more than two-thirds in HYPOX-EXH vs. NORM-EXH (4.2 0.5 vs. 13.4 0.8 min, P 0.01); however, peripheral fatigue was not different in HYPOX-EXH vs. NORM-EXH ( 34 4 vs. 39 4%, P 0.05). Blood lactate concentration and perceptions of limb discomfort were higher throughout HYPOX-EXH vs. NORM-CTRL but were not different at end-exercise in HYPOX-EXH vs. NORM-EXH. We conclude that severe hypoxia exacerbates peripheral fatigue of limb locomotor muscles and that this effect may contribute, in part, to the early termination of exercise.en_US
dc.format.extentR598 - R606-
dc.format.extentR598 - R606-
dc.language.isoenen_US
dc.relation.isreplacedby2438/10071-
dc.relation.isreplacedbyhttp://bura.brunel.ac.uk/handle/2438/10071-
dc.subjectHypoxemiaen_US
dc.subjectMuscle fatigueen_US
dc.subjectExercise performanceen_US
dc.titleEffect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humansen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1152/ajpregu.00269.2006-
dc.relation.isPartOfAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology-
dc.relation.isPartOfAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology-
pubs.issue1-
pubs.issue1-
pubs.volume292-
pubs.volume292-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Sport
Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Notice.pdf44.44 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.