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dc.contributor.authorGreen, C-
dc.contributor.authorBrian, J-
dc.contributor.authorKanda, R-
dc.contributor.authorScholze, M-
dc.contributor.authorWilliams, R-
dc.contributor.authorJobling, S-
dc.date.accessioned2015-01-14T15:11:28Z-
dc.date.available2015-01-14T15:11:28Z-
dc.date.issued2015-
dc.identifier.citationAquatic Toxicology, 160, pp. 117–127, (2015)en_US
dc.identifier.issn0166-445X-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9753-
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractSexual disruption in wild fish has been linked to the contamination of river systems with steroid oestrogens, including the pharmaceutical 17α-ethinylestradiol, originating from domestic wastewaters. As analytical chemistry has advanced, more compounds derived from the human usage of pharmaceuticals have been identified in the environment and questions have arisen as to whether these additional pharmaceuticals may also impact sexual disruption in fish. Indeed, pharmaceutical anti-androgens have been shown to induce such effects under laboratory conditions. These are of particular interest since anti-androgenic biological activity has been identified in the aquatic environment and is potentially implicated in sexual disruption alone and in combination with steroid oestrogens. Consequently, predictive modelling was employed to determine the concentrations of two anti-androgenic human pharmaceuticals, bicalutamide and cyproterone acetate, in UK sewage effluents and river catchments and their combined impacts on sexual disruption were then assessed in two fish models. Crucially, fish were also exposed to the anti-androgens in combination with steroid oestrogens to determine whether they had any additional impact on oestrogen induced feminisation. Modelling predicted that the anti-androgenic pharmaceuticals were likely to be widespread in UK river catchments. However, their concentrations were not sufficient to induce significant responses in plasma vitellogenin concentrations, secondary sexual characteristics or gross indices in male fathead minnow or intersex in Japanese medaka alone or in combination with steroid oestrogens. However, environmentally relevant mixtures of oestrone, 17β-oestradiol and 17α-ethinylestradiol did induce vitellogenin and intersex, supporting their role in sexual disruption in wild fish populations. Unexpectedly, a male dominated sex ratio (100% in controls) was induced in medaka and the potential cause and implications are briefly discussed, highlighting the potential of non-chemical modes of action on this endpoint.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectEndocrine disruptionen_US
dc.subjectIntersexen_US
dc.subjectPredictive modellingen_US
dc.subjectMixturesen_US
dc.subjectAnti-androgensen_US
dc.subjectSteroid oestrogensen_US
dc.titleEnvironmental concentrations of anti-androgenic pharmaceuticals do not impact sexual disruption in fish alone or in combination with steroid oestrogensen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.aquatox.2014.12.022-
dc.relation.isPartOfAquatic Toxicology-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health and Environment-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/IfE-
Appears in Collections:Brunel OA Publishing Fund
Institute for the Environment

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