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Title: Multi-scale interaction of particulate flow and the artery wall
Authors: Halliday, I
Atherton, MA
Care, CM
Collins, MW
Evans, D
Evans, PC
Hose, DR
Khir, AW
Konig, CS
Krams, R
Lawford, PV
Lishchuk, SV
Pontrelli, G
Ridger, V
Spencer, TJ
Ventikos, Y
Walker, DC
Watton, PN
Keywords: Multi-scale;Microcirculation;Endothelium;Wall shear stress;Glycocalyx
Issue Date: 2011
Publisher: Elsevier
Citation: Medical Engineering and Physics, 33(7): 840 - 848, (September 2011)
Abstract: We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.
ISSN: 1350-4533
Appears in Collections:Brunel Institute for Bioengineering (BIB)
Mechanical and Aerospace Engineering

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