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dc.contributor.authorLu, B-
dc.contributor.authorGeorgiou, T-
dc.contributor.authorPamme, N-
dc.contributor.author4th Micro and Nano Flows Conference (MNF2014)-
dc.identifier.citation4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabanien_US
dc.descriptionThis paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community,
dc.description.abstractMicrogels are micrometer sized particles consisting of a polymer network that show potential for the delivery of both hydrophilic and hydrophobic drugs. Microfluidic devices provide an excellent format for the generation of monodispersed droplets due to the precise manipulation of fluids and flow rates within the microchannels. Microfluidic droplet generation chips were therefore designed using T-junction and flow focusing geometries in glass. For microgel synthesis, monomers, crosslinker and initiator were added to the dispersed phase and water was used as the continuous phase. Controlled formation of monodisperse droplets was achieved with both geometries and droplets were collected off-chip for photopolymerisation. Three types of microgel were formed using this setup: poly(ethylene glycol) diacrylate, poly(propylene glycol) diacrylate, and tetrahydropyran acrylate - ethylene glycol dimethacrylate (THPA-EGDMA) microgels. THPA is a novel material for microgels that can be turned from hydrophobic to amphiphilic by hydrolysation. THPA-EGDMA microgels in particular demonstrated a strong response to pH changes due to the build-up of electrostatic force under high pH, showing potential for the encapsulation and release of drugs.en_US
dc.publisherBrunel University Londonen_US
dc.relation.ispartofseriesID 142-
dc.subjectFlow focusingen_US
dc.titleNovel Microgels Fabricated On Microfluidic Devicesen_US
dc.typeConference Paperen_US
Appears in Collections:Brunel Institute for Bioengineering (BIB)
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