Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9213
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dc.contributor.authorPikhartova, J-
dc.contributor.authorBlane, D-
dc.contributor.authorNetuveli, G-
dc.date.accessioned2014-11-06T13:42:44Z-
dc.date.available2014-05-26-
dc.date.available2014-11-06T13:42:44Z-
dc.date.issued2014-
dc.identifier.citationBMC Public Health, 2014, 14 (1): 505, May 2014en_US
dc.identifier.issn1471-2458-
dc.identifier.urihttp://www.biomedcentral.com/1471-2458/14/505/abstracten
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9213-
dc.descriptionCopyright @ 2014 Pikhartova et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractBackground: Socioeconomic circumstances in childhood and early adulthood may influence the later onset of chronic disease, although such research is limited for type 2 diabetes and its risk factors at the different stages of life. The main aim of the present study is to examine the role of childhood social position and later inflammatory markers and health behaviours in developing type 2 diabetes at older ages using a pathway analytic approach. Methods. Data on childhood and adult life circumstances of 2,994 men and 4,021 women from English Longitudinal Study of Ageing (ELSA) were used to evaluate their association with diabetes at age 50 years and more. The cases of diabetes were based on having increased blood levels of glycated haemoglobin and/or self-reported medication for diabetes and/or being diagnosed with type 2 diabetes. Father's job when ELSA participants were aged 14 years was used as the measure of childhood social position. Current social characteristics, health behaviours and inflammatory biomarkers were used as potential mediators in the statistical analysis to assess direct and indirect effects of childhood circumstances on diabetes in later life. Results: 12.6 per cent of participants were classified as having diabetes. A disadvantaged social position in childhood, as measured by father's manual occupation, was associated at conventional levels of statistical significance with an increased risk of type 2 diabetes in adulthood, both directly and indirectly through inflammation, adulthood social position and a risk score constructed from adult health behaviours including tobacco smoking and limited physical activity. The direct effect of childhood social position was reduced by mediation analysis (standardised coefficient decreased from 0.089 to 0.043) but remained statistically significant (p = 0.035). All three indirect pathways made a statistically significantly contribution to the overall effect of childhood social position on adulthood type 2 diabetes. Conclusions: Childhood social position influences adult diabetes directly and indirectly through inflammatory markers, adulthood social position and adult health behaviours. © 2014Pikhartova et al.; licensee BioMed Central Ltd.en_US
dc.description.sponsorshipEconomic and Social Research Council-funded International Centre for Life Course Studies in Society and Health (RES-596-28-0001).en_US
dc.languageeng-
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.subjectDiabetesen_US
dc.subjectELSAen_US
dc.subjectGlycated haemoglobinen_US
dc.subjectInflammationen_US
dc.subjectLongitudinalen_US
dc.titleThe role of childhood social position in adult type 2 diabetes: Evidence from the English Longitudinal Study of Ageingen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2458-14-505-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Clinical Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Clinical Sciences/Community Health and Public Health-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
Appears in Collections:Biological Sciences
Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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