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Title: Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Authors: Griffith, E
Walker, S
Martin, CA
Vagnarelli, P
Stiff, T
Vernay, B
Al Sanna, N
Saggar, A
Hamel, B
Earnshaw, WC
Jeggo, PA
Jackson, AP
O'Driscoll, M
Keywords: Seckel syndrome;DNA;ATR;Pericentrin
Issue Date: 2008
Publisher: Nature Publishing Group
Citation: Nature Genetics, 40(2), 232 - 236, 2008
Abstract: Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling. Only a single hypomorphic mutation of ATR has been identified in this genetically heterogeneous condition. We now report that mutations in the gene encoding pericentrin (PCNT)—resulting in the loss of pericentrin from the centrosome, where it has key functions anchoring both structural and regulatory proteins—also cause Seckel syndrome. Furthermore, we find that cells of individuals with Seckel syndrome due to mutations in PCNT (PCNT-Seckel) have defects in ATR-dependent checkpoint signaling, providing the first evidence linking a structural centrosomal protein with DNA damage signaling. These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size.
Description: This is the author's accepted manuscript. The final published article is available from at the link below.
ISSN: 1061-4036
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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