Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/8868
Title: Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas
Authors: de Polo, A
Scrimshaw, MD
Keywords: Biotic ligand model;Copper;Carbonic anhydrase;Osmotic gradient;Salinity
Issue Date: 2012
Publisher: Wiley-Blackwell
Citation: Environmental Toxicology and Chemistry, 31(2), 230 - 238, 2012
Abstract: An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine environments. At present, the BLM accounts for the effects of water chemistry on Cu speciation, but it does not consider the influence of water chemistry on the physiology of the organisms. We discuss how chemistry affects Cu toxicity not only by controlling its speciation, but also by affecting the osmoregulatory physiology of the organism, which varies according to salinity. In an attempt to understand the mechanisms of Cu toxicity and predict its impacts, we explore the hypothesis that the common factor linking the main toxic effects of Cu is the enzyme carbonic anhydrase (CA), because it is a Cu target with multiple functions and salinity-dependent expression and activity. According to this hypothesis, the site of action of Cu in marine fish may be not only the gill, but also the intestine, because in this tissue CA plays an important role in ion transport and water adsorption. Therefore, the BLM of Cu toxicity to marine fish should also consider the intestine as a biotic ligand. Finally, we underline the need to incorporate the osmotic gradient into the BLM calculations to account for the influence of physiology on Cu toxicity.
Description: This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.
URI: http://onlinelibrary.wiley.com/doi/10.1002/etc.1705/abstract
http://bura.brunel.ac.uk/handle/2438/8868
DOI: http://dx.doi.org/10.1002/etc.1705
ISSN: 0730-7268
Appears in Collections:Environment
Institute for the Environment

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