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Title: An insight into the diverse roles of surfactant proteins, SP-A and SP-D in innate and adaptive immunity
Authors: Nayak, A
Dodagatta-Marri, E
Tsolaki, AG
Kishore, U
Keywords: Hypersensitivity;Infection;Innate immunity;Macrophage;Pattern recognition receptor;Surfactant
Issue Date: 2012
Publisher: Frontiers
Citation: Front Immunol, 3, 131, 2012
Abstract: Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands on pathogens, allergens, and apoptotic cells, via C-terminal homotrimeric carbohydrate recognition domains, while the collagen region brings about the effector functions via its interaction with cell surface receptors. SP-A and SP-D deal with various pathogens, using a range of innate immune mechanisms such as agglutination/aggregation, enhancement of phagocytosis, and killing mechanisms by phagocytic cells and direct growth inhibition. SP-A and SP-D have also been shown to be involved in the control of pulmonary inflammation including allergy and asthma. Emerging evidence suggest that SP-A and SP-D are capable of linking innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. This review enumerates immunological properties of SP-A and SP-D inside and outside lungs and discusses their importance in human health and disease.
Description: PMCID: PMC3369187
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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