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dc.contributor.authorGuibert, R-
dc.contributor.authorFonta, C-
dc.contributor.authorPlouraboue, F-
dc.contributor.author2nd Micro and Nano Flows Conference (MNF2009)-
dc.identifier.citation2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009en_US
dc.descriptionThis paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.en_US
dc.description.abstractBlood rheology is complex and nonlinear. The effective viscosity variations are important due to red blood cells packing inside capillaries, the socalled FåhræusLindquist effect, whilst concomitantly phase segregation appears in bifurcations. We have performed direct numerical simulations of different nonlinear rheological models of the blood on realistic threedimensional microvascular networks. These simulations point out two significant results. First, various rheological models lead to very similar pressure distributions over the whole range of physiologically relevant hematocrits. Secondly, different models for phase segregation lead to very distinct hematocrit distributions in the microvascular network. Moreover, for all the investigated rheological models, the hematocrit distribution very weakly affects the pressure distribution, when prescribing uniform pressure boundary conditions.en_US
dc.description.sponsorshipThe research was supported by GDR n° 2760 Biomécanique des fluides et des transferts Interaction fluide/structure biologique, the ASUPS A03 and A05 of Paul Sabatier University, Toulouse, France and the ANR project ANR06BLAN023801.en_US
dc.publisherBrunel Universityen_US
dc.subjectCerebral cortexen_US
dc.subjectBlood rheologyen_US
dc.subjectApparent viscosityen_US
dc.subjectFåhræusLindquist effecten_US
dc.subjectPlasma skimmingen_US
dc.titleBlood pressure distribution in microvascular networksen_US
dc.typeConference Paperen_US
Appears in Collections:Brunel Institute for Bioengineering (BIB)
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