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Title: Modelling of the pulsatile blood flow in an arterial tree of retinal vasculature
Authors: Ganesan, PB
He, S
Xu, H
2nd Micro and Nano Flows Conference (MNF2009)
Keywords: Retinal vasculature;Network model;Pulsatile blood flow;Womersley solution;Microcirculation
Issue Date: 2009
Publisher: Brunel University
Citation: 2nd Micro and Nano Flows Conference, Brunel University, West London, UK, 01-02 September 2009
Abstract: The paper presents a numerical investigation of pulsatile blood flow in arterial vasculatures of a mouse retina using a Womersley model incorporating an appropriate outlet boundary impedance at the end of the terminal vessels of the arterial tree (pre-capillary arterioles). The mouse retinal flatmount was prepared for confocal microscopy and the morphometric information of the vasculature was obtained from the confocal images. The pulsatile analysis focused on one of the arterial trees in the retinal vasculature. We included the in vivo viscosity evaluated from the mathematical models of Fahraues-Lindquist effect and the plasma skimming effect in the microcirculation. Comparative investigations of the pulsatile circulation were carried out for cases of constant viscosity, in vivo viscosity, zero and non-zero outlet boundary impedance. In addition, the dependency of the oscillating input impedance at the inlet of the arterial trees on angular frequencies of the oscillation and vessel elasticises was also studied. The study shows the pulsatile blood flow prediction is largely influenced by the outlet boundary impedance. The oscillating input impedance at the inlet of the arterial tree is also found to be significantly dependent on the angular frequency and the Young modulus of the vessel segment.
Description: This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.
ISBN: 978-1-902316-72-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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