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dc.contributor.authorLinden, DEJ-
dc.contributor.authorHabes, I-
dc.contributor.authorJohnston, SJ-
dc.contributor.authorLinden, S-
dc.contributor.authorTatineni, R-
dc.contributor.authorSubramanian, L-
dc.contributor.authorSorger, B-
dc.contributor.authorHealy, D-
dc.contributor.authorGoebel, R-
dc.identifier.citationPLoS One, 7(6): e38115, Jun 2012en_US
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright @ 2012 Linden et al.en_US
dc.description.abstractMany patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and neurobiological approaches through neurofeedback with functional magnetic resonance imaging (fMRI). In a proof-of-concept study, eight patients with depression learned to upregulate brain areas involved in the generation of positive emotions (such as the ventrolateral prefrontal cortex (VLPFC) and insula) during four neurofeedback sessions. Their clinical symptoms, as assessed with the 17-item Hamilton Rating Scale for Depression (HDRS), improved significantly. A control group that underwent a training procedure with the same cognitive strategies but without neurofeedback did not improve clinically. Randomised blinded clinical trials are now needed to exclude possible placebo effects and to determine whether fMRI-based neurofeedback might become a useful adjunct to current therapies for depression.en_US
dc.description.sponsorshipThis work was supported by the Wales Institute of Cognitive Neuroscience with funds from the Welsh Assembly Government and by the Medical Research Council (grant reference G1100629/1).en_US
dc.publisherPublic Library of Scienceen_US
dc.titleReal-time self-regulation of emotion networks in patients with depressionen_US
dc.typeResearch Paperen_US
Appears in Collections:Dept of Life Sciences Research Papers

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