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dc.contributor.authorGeorge, K-
dc.contributor.authorOxborough, D-
dc.contributor.authorForster, J-
dc.contributor.authorWhyte, G-
dc.contributor.authorShave, R-
dc.contributor.authorDawson, E-
dc.contributor.authorStephenson, C-
dc.contributor.authorDugdill, L-
dc.contributor.authorEdwards, B-
dc.contributor.authorGaze, D-
dc.identifier.citationThe Journal of Physiology 569(1): 305 - 313, Nov 2005en_US
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2005 The Physiological society.en_US
dc.description.abstractWe assessed segmental and global left ventricular (LV) diastolic function via tissue-Doppler imaging (TDI) as well as Doppler flow variables before and after a marathon race to extend our knowledge of exercise-induced changes in cardiac function. Twenty-nine subjects (age 18–62 year) volunteered to participate and were assessed pre- and post-race. Measurements of longitudinal plane TDI myocardial diastolic velocities at five sites on the mitral annulus included peak early myocardial tissue velocity (E′), peak late (or atrial) myocardial tissue velocity (A′) and the ratio E′/A′. Standard pulsed-wave Doppler transmitral and pulmonary vein flow indices were also recorded along with measurements of body mass, heart rate, blood pressures and cardiac troponin T (cTnT), a biomarker of myocyte damage. Pre- to post-race changes in LV diastolic function were analysed by repeated measures ANOVA. Delta scores for LV diastolic function were correlated with each other and alterations in indices of LV loading. Diastolic longitudinal segmental and mean TDI data were altered post-race such that the mean E′/A′ ratio was significantly depressed (1.51 ± 0.34 to 1.16 ± 0.35, P < 0.05). Changes in segmental and global TDI data were not related to an elevated post-race HR, a decreased post-race pre-load or an elevated cTnT. The pulsed wave Doppler ratio of peak early transmitral flow velocity (E)/peak late (or atrial) flow velocity (A) was also significantly reduced post-race (1.75 ± 0.46 to 1.05 ± 0.30, P < 0.05); however, it was significantly correlated with post-race changes in heart rate. The lack of change in E/E′ from pre- to post-race (3.4 ± 0.8 and 3.3 ± 0.7, respectively) suggests that the depression in diastolic function is likely to be due to altered relaxation of the left ventricle; however, the exact aetiology of this change remains to be determined.en_US
dc.publisherThe Physiological Societyen_US
dc.titleMitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humansen_US
dc.typeResearch Paperen_US
Appears in Collections:Sport
Dept of Life Sciences Research Papers

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