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Title: Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy
Authors: Lv, J
Cao, J
Cai, Y
Zhou, Y
Long, Q
Yao, W
Xu, S
Issue Date: 2011
Publisher: Hindawi Publishing Corporation
Citation: Journal of Applied Mathematics, Article 190371, Mar 2011
Abstract: To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.
Description: This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi Publishing
ISSN: 1110-757X
Appears in Collections:Mechanical and Aerospace Engineering
Brunel OA Publishing Fund
Dept of Mechanical Aerospace and Civil Engineering Research Papers

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