Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/5542
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMiller, D-
dc.contributor.authorWheals, BB-
dc.contributor.authorBeresford, NA-
dc.contributor.authorSumpter, JP-
dc.date.accessioned2011-07-11T11:07:48Z-
dc.date.available2011-07-11T11:07:48Z-
dc.date.issued2001-
dc.identifier.citationEnvironmental Health Perspectives 109(2): 133 - 138, Feb 2001en_US
dc.identifier.issn0091-6765-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/5542-
dc.descriptionCopyright @ 2001 Environmental Health Perspectivesen_US
dc.description.abstractWe used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17<beta>-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.en_US
dc.description.sponsorshipThis work was supported in part under contract with the U.K. Department of Trade and Industry as part of the Government Chemist Programme.en_US
dc.languageEN-
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciences (NIEHS)en_US
dc.subjectEstrogenic activityen_US
dc.subjectPhenolic additivesen_US
dc.subjectRecombinant yeast assayen_US
dc.titleEstrogenic activity of phenolic additives determined by an in vitro yeast bioassayen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1289/ehp.01109133-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel (Active)-
pubs.organisational-data/Brunel/Brunel (Active)/Institute for the Environment-
pubs.organisational-data/Brunel/Brunel (Active)/Research Centres-
pubs.organisational-data/Brunel/Institute for the Environment-
pubs.organisational-data/Brunel/Research Centres-
Appears in Collections:Publications

Files in This Item:
File Description SizeFormat 
Fulltext.pdf117.27 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.