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dc.contributor.authorMiller, D-
dc.contributor.authorWheals, BB-
dc.contributor.authorBeresford, NA-
dc.contributor.authorSumpter, JP-
dc.identifier.citationEnvironmental Health Perspectives 109(2): 133 - 138, Feb 2001en_US
dc.descriptionCopyright @ 2001 Environmental Health Perspectivesen_US
dc.description.abstractWe used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17<beta>-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.en_US
dc.description.sponsorshipThis work was supported in part under contract with the U.K. Department of Trade and Industry as part of the Government Chemist Programme.en_US
dc.publisherNational Institute of Environmental Health Sciences (NIEHS)en_US
dc.subjectEstrogenic activityen_US
dc.subjectPhenolic additivesen_US
dc.subjectRecombinant yeast assayen_US
dc.titleEstrogenic activity of phenolic additives determined by an in vitro yeast bioassayen_US
pubs.organisational-data/Brunel/Brunel (Active)-
pubs.organisational-data/Brunel/Brunel (Active)/Institute for the Environment-
pubs.organisational-data/Brunel/Brunel (Active)/Research Centres-
pubs.organisational-data/Brunel/Institute for the Environment-
pubs.organisational-data/Brunel/Research Centres-
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