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|Title:||How much of the intraaortic balloon volume is displaced toward the coronary circulation?|
|Keywords:||Intra-Aortic Balloon Pump (IABP);Coronary circulation;Heart;Aorta;IAB inflation|
|Publisher:||The American Association for Thoracic Surgery|
|Citation:||Journal of Thoracic and Cardiovascular Surgery, 140(1): 110-116, July 2010|
|Abstract:||Objective: During intraaortic balloon inflation, blood volume is displaced toward the heart (Vtip), traveling retrograde in the descending aorta, passing by the arch vessels, reaching the aortic root (Vroot), and eventually perfusing the coronary circulation (Vcor). Vcor leads to coronary flow augmentation, one of the main benefits of the intraaortic balloon pump. The aim of this study was to assess Vroot and Vcor in vivo and in vitro, respectively. Methods: During intraaortic balloon inflation, Vroot was obtained by integrating over time the aortic root flow signals measured in 10 patients with intraaortic balloon assistance frequencies of 1:1 and 1:2. In a mock circulation system, flow measurements were recorded simultaneously upstream of the intraaortic balloon tip and at each of the arch and coronary branches of a silicone aorta during 1:1 and 1:2 intraaortic balloon support. Integration over time of the flow signals during inflation yielded Vcor and the distribution of Vtip. Results: In patients, Vroot was 6.4% ± 4.8% of the intraaortic balloon volume during 1:1 assistance and 10.0% ± 5.0% during 1:2 assistance. In vitro and with an artificial heart simulating the native heart, Vcor was smaller, 3.7% and 3.8%, respectively. The distribution of Vtip in vitro varied, with less volume displaced toward the arch and coronary branches and more volume stored in the compliant aortic wall when the artificial heart was not operating. Conclusion: The blood volume displaced toward the coronary circulation as the result of intraaortic balloon inflation is a small percentage of the nominal intraaortic balloon volume. Although small, this percentage is still a significant fraction of baseline coronary flow.|
|Description:||This is a post-print version of the published article. Copyright @ 2010 The American Association for Thoracic Surgery.|
This article has been made available through the Brunel Open Access Publishing Fund.
|Appears in Collections:||Brunel Institute for Bioengineering (BIB)|
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