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Title: Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3
Authors: Chen, X
Tang, TS
Tu, H
Nelson, O
Pook, M
Hammer, R
Nukina, N
Bezprozvanny, I
Keywords: SCA3;MJD
Issue Date: 2008
Publisher: Society for Neuroscience
Citation: The Journal of Neuroscience. 28(48): 12713-12724
Abstract: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein. In biochemical experiments we demonstrate that mutant SCA3exp specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1), an intracellular calcium (Ca2+) release channel. In electrophysiological and Ca2+ imaging experiments we show that InsP3R1 are sensitized to activation by InsP3 in the presence of mutant SCA3exp. We found that feeding SCA3-YAC-84Q transgenic mice with dantrolene, a clinically relevant stabilizer of intracellular Ca2+ signaling, improved their motor performance and prevented neuronal cells loss in pontine nuclei and substantia nigra regions. Our results indicate that deranged Ca2+ signaling may play an important role in SCA3 pathology and that Ca2+ signaling stabilizers such as dantrolene may be considered as potential therapeutic drugs for treatment of SCA3 patients.
Appears in Collections:Community Health and Public Health
Dept of Life Sciences Research Papers

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