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Title: Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model
Authors: Argaman, M
Gidron, Y
Ariad, S
Keywords: Hopelessness; Cancer; Progression; Psychoneuroimmunology; IL-1β
Issue Date: 2005
Publisher: Lawrence Erlbaum Associates
Citation: International Journal of Behavioral Medicine. 12(3): 16 -170
Abstract: A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations of IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.
Appears in Collections:Community Health and Public Health
Dept of Clinical Sciences Research Papers

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