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|Title:||Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations|
|Citation:||Biochemical Society Transactions. 33 ( 6) 1438-1440|
|Abstract:||Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration and premature aging have been linked with mutations in lamin A or emerin. These are termed laminopathies, withmutations in emerin causing Emery–Dreifuss muscular dystrophy. Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected.|
|Appears in Collections:||Biological Sciences|
Dept of Life Sciences Research Papers
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