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dc.contributor.authorCroft, J-
dc.contributor.authorBridger, JM-
dc.contributor.authorBoyle, S-
dc.contributor.authorPerry, P-
dc.contributor.authorTeague, P-
dc.contributor.authorBickmore, WA-
dc.identifier.citationThe Journal of Cell Biology. 145 (6) 1119-1131en
dc.description.abstractUsing fluorescence in situ hybridization we show striking differences in nuclear position, chromosome morphology, and interactions with nuclear substructure for human chromosomes 18 and 19. Human chromosome 19 is shown to adopt a more internal position in the nucleus than chromosome 18 and to be more extensively associated with the nuclear matrix. The more peripheral localization of chromosome 18 is established early in the cell cycle and is maintained thereafter. We show that the preferential localization of chromosomes 18 and 19 in the nucleus is reflected in the orientation of translocation chromosomes in the nucleus. Lastly, we show that the inhibition of transcription can have gross, but reversible, effects on chromosome architecture. Our data demonstrate that the distribution of genomic sequences between chromosomes has implications for nuclear structure and we discuss our findings in relation to a model of the human nucleus that is functionally compartmentalized.en
dc.format.extent1057657 bytes-
dc.publisherRockefeller University Pressen
dc.subjectchromosome territories ; genome organization ; nuclear compartmentalization ; transcription ; translocationsen
dc.titleDifferences in the localization and morphology of chromosomes in the human nucleusen
dc.typeResearch Paperen
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

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