Please use this identifier to cite or link to this item:
Title: Is there a link between telomere maintenance and radiosensitivity?
Authors: Slijepcevic, P
Issue Date: 2004
Publisher: Radiation Research Society
Citation: Radiation Research. 161 (1) 82-86
Abstract: Several recent studies point to the possibility that telomere maintenance may constitute a potential genetic marker of radiosensitivity. For example, the human diseases ataxia telangiectasia and Nijmegen breakage syndrome, which are characterized by clinical radiosensitivity, show alterations in telomere maintenance. In addition, Fanconi's anemia patients, who are characterized by mild cellular radiosensitivity and in some cases marked clinical radiosensitivity, have altered telomere maintenance. Similarly, a correlation between telomere maintenance and cellular radiosensitivity was reported in a group of breast cancer patients. Another study demonstrated that radiosensitivity may be more pronounced in human fibroblasts with short telomeres than in their counterparts with long telomeres. Several mouse models including mice deficient in Ku, DNA-PKcs (Prkdc), Parp and Atm, all of which are radiosensitive in vivo, show clear telomere alterations. The link between telomere maintenance and radiosensitivity is also apparent in mice genetically engineered to have dysfunctional telomeres. Finally, studies using non-mammalian model systems such as C. elegans and yeast point to the link between radiosensitivity and telomere maintenance. These results warrant further investigation to identify the extent to which these two phenotypes, namely radiosensitivity and telomere maintenance, are linked.
Appears in Collections:Biological Sciences
Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
predrag.slijepcevic.txt421 BTextView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.