Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/14907
Title: An integrated encyclopedia of DNA elements in the human genome
Authors: Dunham, I
Kundaje, A
Aldred, SF
Collins, PJ
Davis, C
Doyle, F
Epstein, CB
Frietze, S
Harrow, J
Kaul, R
Khatun, J
Kingswood, C
Li, G
Luo, OJ
Park, E
Preall, JB
Presaud, K
Ribeca, P
Risk, BA
Robyr, D
Shoresh, N
Weng, Z
Ruan, X
Sammeth, M
Sandhu, KS
Schaeffer, L
See, L-H
Shahab, A
Skancke, J
Suzuki, AM
Takahashi, H
Tilgner, H
White, KP
Simon, JM
Trout, D
Walters, N
Wang, H
Wrobel, J
Yu, Y
Hayashizaki, Y
Harrow, J
Gerstein, M
Hubbard, TJ
Wold, B
Reymond, A
Song, L
Antonarakis, SE
Hannon, GJ
Giddings, MC
Ruan, Y
Wold, B
Carninci, P
Guigo, R
Gingeras, TR
Khatun, J
Rosenbloom, KR
Sloan, CA
Trinklein, ND
Learned, K
Malladi, VS
Wong, MC
Barber, G
Cline, MS
Dreszer, TR
Heitner, SG
Yu, Y
Karolchik, D
Kent, WJ
Kirkup, VM
Altshuler, RC
Meyer, LR
Long, JC
Maddren, M
Raney, BJ
Furey, TS
Song, L
Wrobel, J
Grasfeder, LL
Giresi, PG
Lee, B-K
Battenhouse, A
Birney, E
Sheffield, NC
Simon, JM
Showers, KA
Safi, A
London, D
Risk, BA
Bhinge, AA
Shestak, C
Schaner, MR
Kim, SK
Zhang, ZZ
Brown, JB
Mieczkowski, PA
Mieczkowska, JO
Liu, Z
McDaniell, RM
Gunawardena, HP
Ni, Y
Rashid, NU
Kim, MJ
Adar, S
Zhang, Z
Wang, T
Cheng, C
Winter, D
Keefe, D
Birney, E
Kuiper, HC
Iyer, VR
Lieb, JD
Crawford, GE
Li, G
Sandhu, KS
Zheng, M
Wang, P
Djebali, S
Luo, OJ
Shahab, A
Maier, CW
Fullwood, MJ
Ruan, X
Ruan, Y
Myers, RM
Pauli, F
Williams, BA
Gertz, J
Marinov, GK
Dong, X
Reddy, TE
Lajoie, BR
Vielmetter, J
Partridge, EC
Trout, D
Varley, KE
Gasper, C
Bansal, A
Pepke, S
Jain, P
Amrhein, H
Dunham, I
Xie, L
Bowling, KM
Anaya, M
Cross, MK
King, B
Muratet, MA
Antoshechkin, I
Newberry, KM
Mccue, K
Nesmith, AS
Fisher-Aylor, KI
Chen, X
Ernst, J
Pusey, B
DeSalvo, G
Parker, SL
Balasubramanian, S
Davis, NS
Meadows, SK
Eggleston, T
Gunter, C
Newberry, JS
Giddings, MC
Levy, SE
Furey, TS
Absher, DM
Mortazavi, A
Wong, WH
Wold, B
Blow, MJ
Visel, A
Pennachio, LA
Elnitski, L
Bernstein, BE
Margulies, EH
Parker, SCJ
Gerstein, M
Petrykowska, HM
Abyzov, A
Aken, B
Barrell, D
Barson, G
Berry, A
Bignell, A
Epstein, CB
Boychenko, V
Bussotti, G
Chrast, J
Giardine, B
Davidson, C
Derrien, T
Despacio-Reyes, G
Diekhans, M
Ezkurdia, I
Frankish, A
Shoresh, N
Gilbert, J
Gonzalez, JM
Griffiths, E
Harte, R
Greven, M
Hendrix, DA
Howald, C
Hunt, T
Jungreis, I
Kay, M
Ernst, J
Khurana, E
Kokocinski, F
Leng, J
Lin, MF
Loveland, J
Hardison, RC
Lu, Z
Manthravadi, D
Mariotti, M
Mudge, J
Kheradpour, P
Mukherjee, G
Notredame, C
Pei, B
Rodriguez, JM
Saunders, G
Sboner, A
Harris, RS
Searle, S
Sisu, C
Snow, C
Mikkelsen, TS
Steward, C
Tanzer, A
Tapanari, E
Tress, ML
van Baren, MJ
Walters, N
Washietl, S
Herrero, J
Wilming, L
Zadissa, A
Gillespie, S
Zhang, Z
Brent, M
Haussler, D
Kellis, M
Valencia, A
Gerstein, M
Reymond, A
Guigo, R
Hoffman, MM
Harrow, J
Landt, SG
Hubbard, TJ
Landt, SG
Frietze, S
Abyzov, A
Addleman, N
Alexander, RP
Auerbach, RK
Balasubramanian, S
Bettinger, K
Iyer, S
Goren, A
Bhardwaj, N
Boyle, AP
Cao, AR
Cayting, P
Charos, A
Cheng, Y
Cheng, C
Eastman, C
Euskirchen, G
Fleming, JD
Ram, O
Kellis, M
Grubert, F
Habegger, L
Hariharan, M
Harmanci, A
Iyengar, S
Jin, VX
Karczewski, KJ
Kasowski, M
Lacroute, P
Zhang, X
Lam, H
Khatun, J
Lamarre-Vincent, N
Leng, J
Lian, J
Lindahl-Allen, M
Min, R
Miotto, B
Monahan, H
Moqtaderi, Z
Wang, L
Mu, XJ
O'Geen, H
Kheradpour, P
Ouyang, Z
Patacsil, D
Pei, B
Raha, D
Ramirez, L
Reed, B
Rozowsky, J
Issner, R
Sboner, A
Shi, M
Sisu, C
Kundaje, A
Slifer, T
Witt, H
Wu, L
Xu, X
Yan, K-K
Yang, X
Coyne, MJ
Yip, KY
Zhang, Z
Struhl, K
Weissman, SM
Lassmann, T
Gerstein, M
Farnham, PJ
Snyder, M
Tenenbaum, SA
Penalva, LO
Durham, T
Doyle, F
Karmakar, S
Landt, SG
Bhanvadia, RR
Choudhury, A
Li, Q
Domanus, M
Ma, L
Moran, J
Patacsil, D
Ku, M
Slifer, T
Victorsen, A
Yang, X
Snyder, M
White, KP
Auer, T
Lin, X
Centanin, L
Eichenlaub, M
Gruhl, F
Truong, T
Heermann, S
Hoeckendorf, B
Inoue, D
Kellner, T
Kirchmaier, S
Mueller, C
Reinhardt, R
Marinov, GK
Schertel, L
Schneider, S
Ward, LD
Sinn, R
Wittbrodt, B
Wittbrodt, J
Weng, Z
Whitfield, TW
Wang, J
Collins, PJ
Aldred, SF
Merkel, A
Trinklein, ND
Lee, B-K
Partridge, EC
Myers, RM
Dekker, J
Jain, G
Lajoie, BR
Sanyal, A
Balasundaram, G
Bates, DL
Byron, R
Mortazavi, A
Altshuler, RC
Canfield, TK
Diegel, MJ
Dunn, D
Ebersol, AK
Frum, T
Garg, K
Gist, E
Hansen, RS
Boatman, L
Haugen, E
Eaton, ML
Parker, SCJ
Humbert, R
Jain, G
Johnson, AK
Johnson, EM
Kutyavin, TV
Lajoie, BR
Lee, K
Lotakis, D
Maurano, MT
Kellis, M
Neph, SJ
Reddy, TE
Neri, FV
Nguyen, ED
Qu, H
Reynolds, AP
Roach, V
Rynes, E
Sabo, P
Sanchez, ME
Djebali, S
Sandstrom, RS
Sanyal, A
Rozowsky, J
Shafer, AO
Stergachis, AB
Thomas, S
Thurman, RE
Vernot, B
Vierstra, J
Vong, S
Davis, CA
Wang, H
Weaver, MA
Yan, Y
Schlesinger, F
Zhang, M
Akey, JM
Bender, M
Dorschner, MO
Groudine, M
MacCoss, MJ
Merkel, A
Navas, P
Stamatoyannopoulos, G
Kaul, R
Dekker, J
Thurman, RE
Stamatoyannopoulos, JA
Dunham, I
Beal, K
Brazma, A
Flicek, P
Dobin, A
Herrero, J
Johnson, N
Keefe, D
Lukk, M
Luscombe, NM
Wang, J
Sobral, D
Vaquerizas, JM
Wilder, SP
Batzoglou, S
Lassmann, T
Sidow, A
Hussami, N
Kyriazopoulou-Panagiotopoulou, S
Libbrecht, MW
Schaub, MA
Kundaje, A
Ward, LD
Hardison, RC
Miller, W
Giardine, B
Mortazavi, A
Harris, RS
Wu, W
Bickel, PJ
Banfai, B
Boley, NP
Brown, JB
Huang, H
Whitfield, TW
Li, Q
Li, JJ
Tanzer, A
Noble, WS
Bilmes, JA
Buske, OJ
Hoffman, MM
Sahu, AD
Kharchenko, PV
Park, PJ
Baker, D
Wilder, SP
Taylor, J
Pauli, F
Weng, Z
Iyer, S
Dong, X
Greven, M
Lin, X
Wang, J
Xi, HS
Zhuang, J
Gerstein, M
Wu, W
Lagarde, J
Alexander, RP
Balasubramanian, S
Cheng, C
Harmanci, A
Lochovsky, L
Min, R
Mu, XJ
Rozowsky, J
Yan, K-K
Yip, KY
Lin, W
Xi, HS
Birney, E
Yip, KY
Zhuang, J
Bernstein, BE
Birney, E
Dunham, I
Green, ED
Gunter, C
Snyder, M
Schlesinger, F
Pazin, MJ
Lowdon, RF
Dillon, LAL
Adams, LB
Kelly, CJ
Zhang, J
Wexler, JR
Green, ED
Good, PJ
Feingold, EA
Xue, C
Bernstein, BE
Birney, E
Crawford, GE
Dekker, J
Elnitski, L
Farnham, PJ
Gerstein, M
Giddings, MC
Gingeras, TR
Green, ED
Marinov, GK
Guigo, R
Hardison, RC
Hubbard, TJ
Kellis, M
Kent, WJ
Lieb, JD
Margulies, EH
Myers, RM
Snyder, M
Stamatoyannopoulos, JA
Khatun, J
Tenenbaum, SA
Williams, BA
Zaleski, C
Rozowsky, J
Roeder, M
Rosenbloom, KR
Kokocinski, F
Abdelhamid, RF
Alioto, T
Antoshechkin, I
Baer, MT
Batut, P
Bell, I
Bell, K
Chakrabortty, S
Chen, X
Sabo, P
Chrast, J
Curado, J
Derrien, T
Drenkow, J
Dumais, E
Dumais, J
Duttagupta, R
Fastuca, M
Fejes-Toth, K
Ferreira, P
Safi, A
Foissac, S
Fullwood, MJ
Gao, H
Gonzalez, D
Gordon, A
Gunawardena, HP
Howald, C
Jha, S
Johnson, R
Kapranov, P
Sanyal, A
King, B
Keywords: Science & Technology;Multidisciplinary Sciences;Science & Technology - Other Topics;MULTIDISCIPLINARY SCIENCES;TRANSCRIPTION FACTOR-BINDING;CHROMOSOME CONFORMATION CAPTURE;HUMAN-CELLS;IN-VIVO;CHROMATIN;REGIONS;MOUSE;MAPS;WIDE;DETERMINANTS
Issue Date: 2012
Publisher: NATURE PUBLISHING GROUP
Citation: NATURE, 2012, 489 (7414), pp. 57 - 74 (18)
Abstract: The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure, and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall the project provides new insights into the organization and regulation of our genes and genome, and an expansive resource of functional annotations for biomedical research.
URI: http://bura.brunel.ac.uk/handle/2438/14907
DOI: http://dx.doi.org/10.1038/nature11247
ISSN: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308347000039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308347000039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
0028-0836
Appears in Collections:Dept of Life Sciences Research Papers

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