Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/14657
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dc.contributor.authorBuxton, JL-
dc.contributor.authorSuderman, M-
dc.contributor.authorPappas, JJ-
dc.contributor.authorBorghol, N-
dc.contributor.authorMcArdle, W-
dc.contributor.authorBlakemore, AIF-
dc.contributor.authorHertzman, C-
dc.contributor.authorPower, C-
dc.contributor.authorSzyf, M-
dc.contributor.authorPembrey, M-
dc.date.accessioned2017-06-01T13:01:28Z-
dc.date.available2014-05-14-
dc.date.available2017-06-01T13:01:28Z-
dc.date.issued2014-
dc.identifier.citationSCIENTIFIC REPORTS, (2014)en_US
dc.identifier.issnhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335812200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5-
dc.identifier.issnARTN 4954-
dc.identifier.issnhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335812200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5-
dc.identifier.issnARTN 4954-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/14657-
dc.description.abstractIn humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL is associated with increased risk of age-related disease. In this study we tested for association between telomere length and methylated cytosine levels. Measurements of mean telomere length and DNA methylation at .450,000 CpG sites were obtained for both blood (N 5 24) and EBV-transformed cell-line (N 5 36) DNA samples from men aged 44–45 years. We identified 65 gene promoters enriched for CpG sites at which methylation levels are associated with leukocyte telomere length, and 36 gene promoters enriched for CpG sites at which methylation levels are associated with telomere length in DNA from EBV-transformed cell-lines.Weobserved significant enrichment of positively associated methylated CpG sites in subtelomeric loci (within 4 Mb of the telomere) (P , 0.01), and also at loci in imprinted regions (P , 0.001). Our results pave the way for further investigations to help elucidate the relationships between telomere length, DNA methylation and gene expression in health and disease.en_US
dc.description.sponsorshipThe Section of Investigative Medicine at Imperial College London is funded by grants from the MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, and FP7- HEALTH- 2009- 241592 EuroCHIP grant and is supported by the NIHR www.nature.com/scientificreports SCIENTIFIC REPORTS | 4 : 4954 | DOI: 10.1038/srep04954 7 Imperial Biomedical Research Centre Funding Scheme. For the 1958 Birth Cohort samples, venous blood collection was funded by the UK Medical Research Council (G0000934) and cell-line production, DNA extraction and processing by the Wellcome Trust (068545/Z/ 02). MS was supported by a grant from the Canadian Institute for Health Research MOP-42411. This work was also funded by aWellcome Trust programme grant 072937/Z/ 03/Z awarded to MP, and a Wellcome Trust fellowship grant, WT088431MA, held by JLB.en_US
dc.format.extent? - ? (8)-
dc.languageEnglish-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectScience & Technologyen_US
dc.subjectMultidisciplinary Sciencesen_US
dc.subjectScience & Technology - Other Topicsen_US
dc.subjectMULTIDISCIPLINARY SCIENCESen_US
dc.subjectOXIDATIVE STRESSen_US
dc.subjectSHORTENS TELOMERESen_US
dc.subjectDISEASEen_US
dc.subjectPOSITIONen_US
dc.subjectCELLSen_US
dc.subjectDYSFUNCTIONen_US
dc.subjectSENESCENCEen_US
dc.subjectVIABILITYen_US
dc.subjectINSIGHTSen_US
dc.subjectTISSUESen_US
dc.titleHuman leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted locien_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1038/srep04954-
dc.relation.isPartOfSCIENTIFIC REPORTS-
pubs.publication-statusPublished-
pubs.volume4-
Appears in Collections:Dept of Life Sciences Research Papers

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