Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/13315
Title: The Compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: An Increasingly Complex Puzzle
Authors: Mitta, G
Gourbal, B
Grunau, C
Knight, M
Bridger, JM
Theron, A
Keywords: Biomphalaria glabrata;Compatibility polymorphism;Epigenetic;Immune priming;Schistosomamansoni
Issue Date: 2016
Publisher: Elsevier
Citation: Advances in Parasitology, (2016)
Abstract: This review reexamines the results obtained in recent decades regarding the compatibility polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma mansoni, which is one of the agents responsible for human schistosomiasis. Some results point to the snail's resistance as explaining the incompatibility, while others support a “matching hypothesis” between the snail's immune receptors and the schistosome's antigens. We propose here that the two hypotheses are not exclusive, and that the compatible/incompatible status of a particular host/parasite couple probably reflects the balance of multiple molecular determinants that support one hypothesis or the other. Because these genes are involved in a coevolutionary arms race, we also propose that the underlying mechanisms can vary. Finally, some recent results show that environmental factors could influence compatibility. Together, these results make the compatibility between B. glabrata and S. mansoni an increasingly complex puzzle. We need to develop more integrative approaches in order to find targets that could potentially be manipulated to control the transmission of schistosomiasis.
URI: http://www.sciencedirect.com/science/article/pii/S0065308X16300823
http://bura.brunel.ac.uk/handle/2438/13315
ISSN: 0065-308X
Appears in Collections:Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Fulltext.pdf1.69 MBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.