Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/12971
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKouser, L-
dc.contributor.authorMadhukaran, SP-
dc.contributor.authorShastri, A-
dc.contributor.authorSaraon, A-
dc.contributor.authorFerluga, J-
dc.contributor.authorAl-Mozaini, M-
dc.contributor.authorKishore, U-
dc.date.accessioned2016-07-19T11:09:44Z-
dc.date.available2015-01-01-
dc.date.available2016-07-19T11:09:44Z-
dc.date.issued2015-
dc.identifier.citationFrontiers in Immunology, 6(317): pp. 1-19, (2015)en_US
dc.identifier.issn1664-3224-
dc.identifier.urihttp://journal.frontiersin.org/article/10.3389/fimmu.2015.00317/full-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/12971-
dc.description.abstractComplement protein C1q, the recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells including dendritic cells and microglia. C1q involvement in the clearance of apoptotic cells and subsequent B cell tolerance is more established now. Recent evidence appears to suggest that C1q plays an important role in pregnancy where its deficiency and dysregulation can have adverse effects, leading to preeclampsia, missed abortion, miscarriage or spontaneous loss, and various infections. C1q is also produced locally in the central nervous system, and has a protective role against pathogens and possible inflammatory functions while interacting with aggregated proteins leading to neurodegenerative diseases. C1q role in synaptic pruning, and thus CNS development, its anti-cancer effects as an immune surveillance molecule, and possibly in aging are currently areas of extensive research.en_US
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectComplementen_US
dc.subjectC1qen_US
dc.subjectApoptosisen_US
dc.subjectNeurogenesisen_US
dc.subjectPregnancyen_US
dc.subjectCanceren_US
dc.titleEmerging and novel functions of complement protein C1qen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.3389/fimmu.2015.00317-
dc.relation.isPartOfFrontiers in Immunology-
pubs.issueJUN-
pubs.publication-statusPublished-
pubs.volume6-
Appears in Collections:Publications

Files in This Item:
File Description SizeFormat 
Fulltext.pdf6.05 MBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.