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Title: The time course of endogenous erythropoietin, IL-6, and TNFα in response to acute hypoxic exposures
Authors: Turner, G
Gibson, OR
Watt, PW
Pringle, JSM
Richardson, AJ
Maxwell, NS
Keywords: Hypoxia;EPO;Altitude;Cytokines;Inflammation
Issue Date: 2016
Publisher: John Wiley & Sons Ltd
Citation: Scandinavian Journal of Medicine & Science in Sports, (2016)
Abstract: Erythropoietin (EPO) rapidly decreases on return to sea level (SL) after chronic altitude exposure. Acute hypoxia may provide an additional stimulus to prevent the decline in EPO. Pro-inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα), have been shown to inhibit EPO production. Optimal normobaric hypoxic exposure has not been established; therefore, investigation of methods eliciting the greatest response in EPO, to limit physiological stress is required. Eight males (age 27±4 yrs, body mass 77.5±9.0 kg, height 179±6 cm) performed four passive exposures to different normobaric hypoxic severities [FiO2:0.209 (SL), FiO2:~0.135 (3,600 m), FiO2:~0.125 (4,200 m) and FiO2:~0.115 (4,800 m)] in a hypoxic chamber for 2 h. Venous blood was drawn pre-exposure and then at 1, 2, 4, 6 and 8 h to determine erythropoietin concentration ([EPO]), IL-6 and TNFα. During 4,200 m and 4,800 m [EPO] increased from 5.9±1.5 to 8.1±1.5 mU/mL (P=0.009) and 6.0±1.4 to 8.9±2.0 mU/mL (P=0.037), respectively, with [EPO] increase peaking at 4h (2h post-exposure). There were no differences in IL-6 or TNFα during, or post-exposure. Increased [EPO] was found 2 h post-hypoxic exposure as result of 2 h of normobaric hypoxia ≥4,200 m. There was no dose-response relationship in [EPO] between simulated hypoxia severities.
ISSN: 0905-7188
Appears in Collections:Dept of Life Sciences Research Papers

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