Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/12530
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dc.contributor.authorBurugapalli, K-
dc.contributor.authorBurugapalli, K-
dc.contributor.authorChan, JCY-
dc.contributor.authorKelly, JL-
dc.contributor.authorPandit, AS-
dc.date.accessioned2016-04-20T10:42:21Z-
dc.date.available2014-02-01-
dc.date.available2016-04-20T10:42:21Z-
dc.date.issued2014-
dc.identifier.citationMacromolecular Bioscience, 14, (2): pp. 244 - 256, (2014)en_US
dc.identifier.issn1616-5187-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201300195/epdf-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/12530-
dc.description.abstractCholecyst-derived extracellular matrix (CEM) is a fibro-porous decellularized serosal layer of porcine gall-bladder. CEM loses 90% of its weight at 48 h of in vitro collagenase digestion, but takes two months to be completely resorbed in vivo. Carbodiimide (EDC) crosslinking helps tailoring CEM's in vitro collagenase susceptibility. Here, the efficacy of EDC crosslinking on tailoring in vivo biodegradability of CEM is reported. CEM crosslinked with 0.0005 and 0.0033 × 103 M of EDC/mg that lose 80% and 0% of their weight respectively to in vitro collagenase digestion, were present even after 180 days in vivo. Quantitative histopathology using stereology methods confirmed our qualitative observation that even a tiny degree of crosslinking can significantly prolong the rate of in vivo degradation and removal of CEM. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.format.extent244 - 256-
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectCholecyst-derived extracellular matrixen_US
dc.subjectCrosslinkingen_US
dc.subjectBiodegradationen_US
dc.subjectStereologyen_US
dc.subjectTissue-implant interactionsen_US
dc.titleEfficacy of crosslinking on tailoring in vivo biodegradability of fibro-porous decellularized extracellular matrix and restoration of native tissue structure: A quantitative study using stereology methodsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mabi.201300195-
dc.relation.isPartOfMacromolecular Bioscience-
pubs.issue2-
pubs.publication-statusPublished-
pubs.publication-statusPublished-
pubs.volume14-
Appears in Collections:Institute for the Environment

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