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Title: Local but not long-range microstructural differences of the ventral temporal cortex in developmental prosopagnosia
Authors: Song, S
Garrido, L
Nagy, Z
Mohammadi, S
Steel, A
Driver, J
Dolan, RJ
Duchaine, B
Furl, N
Keywords: Diffusion-weighted imaging;Inferior longitudinal fasciculus;Inferior fronto-occipital fasciculus;Prosopagnosia;Face perception;Individual differences
Issue Date: 2015
Publisher: Elsevier
Citation: Neuropsychologia, 78: pp. 195 - 206, (2015)
Abstract: Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision and no history of brain damage. Prior studies using diffusion tensor imaging in small samples of subjects with DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, with one suggesting white matter differences in two major long-range tracts running through the temporal cortex, and another suggesting white matter differences confined to fibers local to ventral temporal face-specific functional regions of interest (fROIs) in the fusiform gyrus. Here, we address these inconsistent findings using a comprehensive set of analyzes in a sample of DP subjects larger than both prior studies combined (n=16). While we found no microstructural differences in long-range tracts between DP and age-matched control participants, we found differences local to face-specific fROIs, and relationships between these microstructural measures with face recognition ability. We conclude that subtle differences in local rather than long-range tracts in the ventral temporal lobe are more likely associated with developmental prosopagnosia.
ISSN: 0028-3932
Appears in Collections:Dept of Life Sciences Research Papers

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