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Title: Natural AD-like neuropathology in Octodon degus: Impaired burrowing and neuroinflammation
Authors: Deacon, RMJ
Altimiras, FJ
Bazán-León, EA
Pyarasani, RD
Nachtigall, FM
Santos, LS
Tsolaki, AG
Pednekar, L
Kishore, U
Biekofsky, RR
Vásquez, RA
Cogram, P
Keywords: Alzheimer’s disease;Beta-amyloid;Burrowing;Complement;Cytokines;Octodon degus
Issue Date: 2015
Publisher: Bentham Science
Citation: Current Alzheimer Research,12 (4): pp. 314 - 322, (2015)
Abstract: Alzheimer’s disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs of AD, including amyloid-β (Aβ) and tau deposits, as well as a decline in cognition with age. Firstly, the present work introduces a novel behavioral assessment for O. degus - the burrowing test - which appears to be a useful tool for detecting neurodegeneration in the O. degus model for AD. Such characterization has potentially wide-ranging implications, because many of these changes in species-typical behaviors are reminiscent of the impairments in activities of daily living (ADL), so characteristic of human AD. Furthermore, the present work characterizes the ADlike neuropathology in O. degus from a gene expression point of view, revealing a number of previously unreported AD biomarkers, which are found in human AD: amyloid precursor protein (APP), apolipoprotein E (ApoE), oxidative stressrelated genes from the NFE2L2 and PPAR pathway, as well as pro-inflammatory cytokines and complement proteins, in agreement with the known link between neurodegeneration and neuroinflammation. In summary, the present results confirm a natural neuropathology in O. degus with similar characteristics to AD at behavioral, cellular and molecular levels. These characteristics put O. degus in a singular position as a natural rodent model for research into AD pathogenesis and therapeutics against AD.
ISSN: 1567-2050
Appears in Collections:Dept of Life Sciences Research Papers

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