Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10622
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dc.contributor.authorKaur, S-
dc.contributor.authorJobling, S-
dc.contributor.authorJones, CS-
dc.contributor.authorNoble, LR-
dc.contributor.authorRoutledge, EJ-
dc.contributor.authorLockyer, AE-
dc.coverage.spatialUnited States-
dc.coverage.spatialUnited States-
dc.date.accessioned2015-04-22T11:07:52Z-
dc.date.available2015-
dc.date.available2015-04-22T11:07:52Z-
dc.date.issued2015-
dc.identifier.citationPLoS One, 10 (4): e0121259, (7 April 2015)en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121259-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10622-
dc.description© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden_US
dc.description.abstractNuclear receptors (NRs) are transcription regulators involved in an array of diverse physiological functions including key roles in endocrine and metabolic function. The aim of this study was to identify nuclear receptors in the fully sequenced genome of the gastropod snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni and compare these to known vertebrate NRs, with a view to assessing the snail's potential as a invertebrate model organism for endocrine function, both as a prospective new test organism and to elucidate the fundamental genetic and mechanistic causes of disease. For comparative purposes, the genome of a second gastropod, the owl limpet, Lottia gigantea was also investigated for nuclear receptors. Thirty-nine and thirty-three putative NRs were identified from the B. glabrata and L. gigantea genomes respectively, based on the presence of a conserved DNA-binding domain and/or ligand-binding domain. Nuclear receptor transcript expression was confirmed and sequences were subjected to a comparative phylogenetic analysis, which demonstrated that these molluscs have representatives of all the major NR subfamilies (1-6). Many of the identified NRs are conserved between vertebrates and invertebrates, however differences exist, most notably, the absence of receptors of Group 3C, which includes some of the vertebrate endocrine hormone targets. The mollusc genomes also contain NR homologues that are present in insects and nematodes but not in vertebrates, such as Group 1J (HR48/DAF12/HR96). The identification of many shared receptors between humans and molluscs indicates the potential for molluscs as model organisms; however the absence of several steroid hormone receptors indicates snail endocrine systems are fundamentally different.en_US
dc.description.sponsorshipThe National Centre for the Replacement, Refinement and Reduction of Animals in Research, Grant Ref:G0900802 to CSJ, LRN, SJ & EJR [www.nc3rs.org.uk].en_US
dc.format.extente0121259 - ?-
dc.format.extente0121259 - ?-
dc.languageeng-
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectBiomphalaria glabrataen_US
dc.subjectNuclear receptorsen_US
dc.subjectLottia giganteaen_US
dc.subjectNew model organismsen_US
dc.titleThe nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organismsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0121259-
dc.relation.isPartOfPLoS One-
dc.relation.isPartOfPLoS One-
pubs.issue4-
pubs.issue4-
pubs.volume10-
pubs.volume10-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health and Environment-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/IfE-
Appears in Collections:Institute for the Environment

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