Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10566
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dc.contributor.authorBoehler, C-
dc.contributor.authorLord, J-
dc.date.accessioned2015-04-16T10:09:20Z-
dc.date.available2015-04-16-
dc.date.available2015-04-16T10:09:20Z-
dc.date.issued2015-
dc.identifier.citationMedical Decision Making, 2015, Forthcomingen_US
dc.identifier.issn1552-681X-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10566-
dc.description.abstractBackground. Published cost-effectiveness estimates can vary considerably, both within and between countries. Despite extensive discussion, little is known empirically about factors relating to these variations. Objectives. To use multilevel statistical modeling to integrate cost-effectiveness estimates from published economic evaluations to investigate potential causes of variation. Methods. Cost-effectiveness studies of statins for cardiovascular disease prevention were identified by systematic review. Estimates of incremental costs and effects were extracted from reported base case, sensitivity, and subgroup analyses, with estimates grouped in studies and in countries. Three bivariate models were developed: a cross-classified model to accommodate data from multinational studies, a hierarchical model with multinational data allocated to a single category at country level, and a hierarchical model excluding multinational data. Covariates at different levels were drawn from a long list of factors suggested in the literature. Results. We found 67 studies reporting 2094 cost-effectiveness estimates relating to 23 countries (6 studies reporting for more than 1 country). Data and study-level covariates included patient characteristics, intervention and comparator cost, and some study methods (e.g., discount rates and time horizon). After adjusting for these factors, the proportion of variation attributable to countries was negligible in the cross-classified model but moderate in the hierarchical models (14%−19% of total variance). Country-level variables that improved the fit of the hierarchical models included measures of income and health care finance, health care resources, and population risks. Conclusions. Our analysis suggested that variability in published cost-effectiveness estimates is related more to differences in study methods than to differences in national context. Multinational studies were associated with much lower country-level variation than single-country studies. These findings are for a single clinical question and may be atypical.en_US
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.subjectEconomic Evaluationen_US
dc.subjectTransferabilityen_US
dc.subjectExchangeabilityen_US
dc.subjectMultilevel statistical modelingen_US
dc.subjectStatinsen_US
dc.subjectCardiovascular diseaseen_US
dc.titleMind the gap! A multilevel analysis of factors related to variation in published cost-effectiveness estimates within and between countriesen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1177/0272989X15579173-
dc.relation.isPartOfMedical Decision Making-
dc.relation.isPartOfMedical Decision Making-
pubs.publication-statusPublished-
pubs.publication-statusPublished-
pubs.volumeAvailable online-
pubs.volumeAvailable online-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health Economics-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/HERG-
Appears in Collections:Health Economics Research Group (HERG)

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