Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10556
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dc.contributor.authorSutherland, I-
dc.contributor.authorThickitt, C-
dc.contributor.authorDouillet, N-
dc.contributor.authorFreebairn, K-
dc.contributor.authorJohns, D-
dc.contributor.authorMountain, C-
dc.contributor.authorWood, P-
dc.contributor.authorEdwards, N-
dc.contributor.authorRooke, D-
dc.contributor.authorHarris, G-
dc.contributor.authorKeay, D-
dc.contributor.authorMathews, B-
dc.contributor.authorBrown, R-
dc.contributor.authorGarrard, I-
dc.contributor.authorHewitson, P-
dc.contributor.authorIgnatova, S-
dc.date.accessioned2015-04-13T15:48:40Z-
dc.date.available2013-03-22-
dc.date.available2015-04-13T15:48:40Z-
dc.date.issued2013-
dc.identifier.citationJournal of Chromatography A, 2013, 1282 pp. 84 - 94en_US
dc.identifier.issnS0021967313001374-
dc.identifier.issnS0021967313001374-
dc.identifier.issn0021-9673-
dc.identifier.issn1873-3778-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10556-
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractThis paper reports on some of the key outcomes of a 3 year £1.5. m Technology Strategy Board (TSB) funded research programme to develop a small footprint, versatile, counter-current chromatography purification technology and methodology which can be operated at a range of scales in both batch and continuous modes and that can be inserted into existing process plant and systems. Our consortium, integrates technology providers (Dynamic Extractions) and the scientific development team (Brunel) with end user needs (GSK & Pfizer), addressing major production challenges aimed at providing flexible, low capital platform technology driving substantial cost efficiency in both drug development and drug manufacturing processes. The aims of the Technology Strategy Board's high value manufacturing programme are described and how the academic/industry community were challenged to instigate step changes in the manufacturing of high value pharmaceuticals. This paper focusses on one of the themes of the TSB research programme, " Generate a Comprehensive Applications Portfolio" It outlines 15 applications from this portfolio that can be published in the public domain and gives four detailed case studies illustrating the range of application of the technology on the separation of (1) isomers, (2) polar compounds, (3) crude mixtures and (4) on the removal of impurities. Two of these case studies that were scaled up demonstrate between 10 and 20% lower solvent usage and were projected to have significant cost savings compared to conventional solid phase silica gel chromatography at procss scale demonstrating that the latest high performance countercurrent chromatography technology is a competitive platform technolgy for the pharmaceutical industry. © 2013 Elsevier B.V.en_US
dc.format.extent84 - 94-
dc.format.extent84 - 94-
dc.languageeng-
dc.language.isoenen_US
dc.subjectHigh performance counter-current chromatographyen_US
dc.subjectHPCCCen_US
dc.subjectProcess scaleen_US
dc.subjectScale upen_US
dc.titleScalable Technology for the Extraction of Pharmaceutics: Outcomes from a 3 year collaborative industry/academia research programmeen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.chroma.2013.01.049-
dc.relation.isPartOfJournal of Chromatography A-
dc.relation.isPartOfJournal of Chromatography A-
pubs.volume1282-
pubs.volume1282-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering/Mechanical and Aerospace Engineering-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health and Environment-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/BIB-
Appears in Collections:Brunel Institute for Bioengineering (BIB)
Brunel OA Publishing Fund

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