Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10525
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dc.contributor.authorStenbeck, G-
dc.contributor.authorCoxon, FP-
dc.date.accessioned2015-03-30T15:06:45Z-
dc.date.available2014-06-
dc.date.available2015-03-30T15:06:45Z-
dc.date.issued2014-
dc.identifier.citationCurrent Opinion in Pharmacology,16 (1): pp.7 - 14, (2014)en_US
dc.identifier.issnS1471489214000046-
dc.identifier.issn1471-4892-
dc.identifier.issn1471-4973-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10525-
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractVesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such as osteopetrosis, which frequently results from defects in this process. Recent work has further dissected the role of the endolysosomal system in both bone formation by osteoblasts and bone resorption by osteoclasts. This pathway also plays an important role in the communication between these and other cells in bone, through trafficking and degradation of growth factors and their receptors, and microvesicle release. In addition, a crucial role for autophagy in bone remodelling and bone disease is beginning to emerge. These insights into the molecular control of bone remodelling raise the possibility of developing novel therapeutics for bone diseases designed to target specific aspects of this process. © 2014 The Authors.en_US
dc.format.extent7 - 14-
dc.format.extent7 - 14-
dc.languageeng-
dc.language.isoenen_US
dc.subjectVesicular traffickingen_US
dc.subjectBone cellsen_US
dc.subjectOsteoclastsen_US
dc.titleRole of vesicular trafficking in skeletal dynamicsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.coph.2014.01.003-
dc.relation.isPartOfCurrent Opinion in Pharmacology-
dc.relation.isPartOfCurrent Opinion in Pharmacology-
pubs.issue1-
pubs.issue1-
pubs.volume16-
pubs.volume16-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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