Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10522
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dc.contributor.authorFabbri, D-
dc.contributor.authorLong, Q-
dc.contributor.authorDas, S-
dc.contributor.authorPinelli, M-
dc.date.accessioned2015-03-30T11:28:27Z-
dc.date.available2014-
dc.date.available2015-03-30T11:28:27Z-
dc.date.issued2014-
dc.identifier.citationBiomechanics and Modeling in Mechanobiology, 2014, 13 (2), pp. 289 - 302en_US
dc.identifier.issn1617-7959-
dc.identifier.issn1617-7940-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10522-
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractIschaemic stroke is responsible for up to 80 % of stroke cases. Prevention of the reoccurrence of ischaemic attack or stroke for patients who survived the first symptoms is the major treatment target. Accurate diagnosis of the emboli source for a specific infarction lesion is very important for a better treatment for the patient. However, due to the complex blood flow patterns in the cerebral arterial network, little is known so far of the embolic particle flow trajectory and its behaviour in such a complex flow field. The present study aims to study the trajectories of embolic particles released from carotid arteries and basilar artery in a cerebral arterial network and the influence of particle size, mass and release location to the particle distributions, by computational modelling. The cerebral arterial network model, which includes major arteries in the circle of Willis and several generations of branches from them, was generated from MRI images. Particles with diameters of 200, 500 and 800 μ m and densities of 800, 1,030 and 1,300 kg/m 3 were released in the vessel's central and near-wall regions. A fully coupled scheme of particle and blood flow in a computational fluid dynamics software ANASYS CFX 13 was used in the simulations. The results show that heavy particles (density large than blood or a diameter larger than 500 μ m) normally have small travel speeds in arteries; larger or lighter embolic particles are more likely to travel to large branches in cerebral arteries. In certain cases, all large particles go to the middle cerebral arteries; large particles with higher travel speeds in large arteries are likely to travel at more complex and tortuous trajectories; emboli raised from the basilar artery will only exit the model from branches of basilar artery and posterior cerebral arteries. A modified Circle of Willis configuration can have significant influence on particle distributions. The local branch patterns of internal carotid artery to middle cerebral artery and anterior communicating artery can have large impact on such distributions. © 2014 The Author(s).en_US
dc.format.extent289 - 302-
dc.format.extent289 - 302-
dc.languageeng-
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.subjectCerebral arteriesen_US
dc.subjectCircle of Willisen_US
dc.subjectComputational modellingen_US
dc.subjectEmboli size and densityen_US
dc.subjectEmboli travel trajectoriesen_US
dc.subjectIschaemic stroke infarctionen_US
dc.titleComputational modelling of emboli travel trajectories in cerebral arteries: Influence of microembolic particle size and densityen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10237-014-0561-0-
dc.relation.isPartOfBiomechanics and Modeling in Mechanobiology-
dc.relation.isPartOfBiomechanics and Modeling in Mechanobiology-
pubs.issue2-
pubs.issue2-
pubs.volume13-
pubs.volume13-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering/Mechanical and Aerospace Engineering-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Biomedical Engineering and Healthcare Technologies-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/BIB-
Appears in Collections:Brunel OA Publishing Fund
Dept of Mechanical Aerospace and Civil Engineering Research Papers

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