Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10296
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dc.contributor.authorDominelli, PB-
dc.contributor.authorRender, JN-
dc.contributor.authorMolgat-Seon, Y-
dc.contributor.authorFoster, GE-
dc.contributor.authorRomer, LM-
dc.contributor.authorSheel, AW-
dc.date.accessioned2015-02-24T12:34:58Z-
dc.date.available2015-02-24T12:34:58Z-
dc.date.issued2015-
dc.identifier.citationThe Journal of Physiology, (2015)en_US
dc.identifier.issn1469-7793-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.285965/abstract;jsessionid=3BAFE2D4AF921CDEC14CB1DB9F32011C.f03t03-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10296-
dc.descriptionThis is the accepted version of the following article: [Dominelli, P. B., Render, J. N., Molgat-Seon, Y., Foster, G. E., Romer, L. M. and Sheel, A. W. (2015), Oxygen cost of exercise hyperpnoea is greater in women compared with men. The Journal of Physiology. doi: 10.1113/jphysiol.2014.285965], which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.285965/abstract;jsessionid=3BAFE2D4AF921CDEC14CB1DB9F32011C.f03t03en_US
dc.description.abstractWe compared the oxygen cost of breathing (V˙ O2RM) in healthy men and women over a wide range of exercise ventilations (V˙ E). Eighteen subjects (9 women) completed four days of testing. First, a step-wise maximal cycle exercise test was completed for the assessment of spontaneous breathing patterns. Next, subjects were familiarized with the voluntary hyperpnoea protocol used to estimate V˙ O2RM. During the final two visits, subjects mimicked multiple times (4-6) the breathing patterns associated with 5-6 different exercise stages. Each trial lasted 5 min and on-line pressure- and flow-volume loops were superimposed on target loops obtained during exercise to accurately replicate the work of breathing. At ~55 l min-1 V˙ E, V˙ O2RM was significantly greater in women. At maximum ventilation, the absolute V˙ O2RM was not different (P>0.05) between the sexes, but represented a significantly greater fraction of whole-body V˙ O2 in women (13.8±1.5 vs. 9.4±1.1% V˙ O2). During heavy exercise at 92 and 100% V˙ O2max, the unit cost of V˙ E was +0.7 and +1.1 mlO2 l-1 greater in women (P<0.05). At V˙ O2max, men and women who developed expiratory flow limitation had a significantly greater V˙ O2RM than those who did not (435±44 vs. 331±30 mlO2 min-1). In conclusion, women have a greater V˙ O2RM for a given V˙ E and this represents a greater fraction of whole-body V˙ O2. The greater V˙ O2RM in women may have implications for the integrated physiological response to exercise.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectOxygen cost of breathingen_US
dc.subjectExercise ventilationsen_US
dc.subjectVoluntary hyperpnoea protocolen_US
dc.titleOxygen cost of exercise hyperpnoea is greater in women compared with menen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1113/jphysiol.2014.285965-
dc.relation.isPartOfThe Journal of Physiology-
dc.relation.isPartOfThe Journal of Physiology-
pubs.publication-statusAccepted-
pubs.publication-statusAccepted-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Dept of Life Sciences Research Papers

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