Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10269
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dc.contributor.authorAl-Mahdawi, S-
dc.contributor.authorVirmouni, SA-
dc.contributor.authorPook, MA-
dc.date.accessioned2015-02-18T15:37:30Z-
dc.date.available2014-
dc.date.available2015-02-18T15:37:30Z-
dc.date.issued2014-
dc.identifier.citationFrontiers in Neuroscience, 8: (05 December 2014)en_US
dc.identifier.issn1662-4548-
dc.identifier.issn1662-453X-
dc.identifier.urihttp://journal.frontiersin.org/article/10.3389/fnins.2014.00397/abstract-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10269-
dc.descriptionCopyright © 2014 Al-Mahdawi, Anjomani Virmouni and Pook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractDNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes such as development and differentiation. However, recent studies have identified an alternative modification, 5-hydroxymethylcytosine (5hmC), which is formed by oxidation of 5mC by ten-eleven translocation (TET) enzymes. The overall levels of 5hmC in the mammalian genome are approximately 10% of 5mC levels, although higher levels have been detected in tissues of the central nervous system (CNS). The functions of 5hmC are not yet fully known, but evidence suggests that 5hmC may be both an intermediate product during the removal of 5mC by passive or active demethylation processes and also an epigenetic modification in its own right, regulating chromatin or transcriptional factors involved in processes such as neurodevelopment or environmental stress response. This review highlights our current understanding of the role that 5hmC plays in neurodegenerative diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), fragile X-associated tremor/ataxia syndrome (FXTAS), Friedreich ataxia (FRDA), Huntington's disease (HD), and Parkinson's disease (PD).en_US
dc.description.sponsorshipSara Anjomani Virmouni was supported by funding to Mark A. Pook from the Friedreich’s Ataxia Research Alliance(FARA).en_US
dc.languageeng-
dc.publisherFrontiers Research Foundationen_US
dc.subject5-hydroxymethylcytosineen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectAmyotrophic lateral sclerosisen_US
dc.subjectFragile X-associated tremor/ataxia syndromeen_US
dc.subjectFriedreich ataxiaen_US
dc.subjectHuntington's diseaseen_US
dc.subjectParkinson's diseaseen_US
dc.titleThe emerging role of 5-hydroxymethylcytosine in neurodegenerative diseasesen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.3389/fnins.2014.00397-
dc.relation.isPartOfFrontiers in Neuroscience-
dc.relation.isPartOfFrontiers in Neuroscience-
pubs.issueDEC-
pubs.issueDEC-
pubs.volume8-
pubs.volume8-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Brunel OA Publishing Fund
Dept of Life Sciences Research Papers

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