Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10265
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dc.contributor.authorYang, Y-
dc.contributor.authorRowen, D-
dc.contributor.authorBrazier, J-
dc.contributor.authorTsuchiya, A-
dc.contributor.authorYoung, T-
dc.contributor.authorLongworth, L-
dc.date.accessioned2015-02-18T12:46:55Z-
dc.date.available2015-01-01-
dc.date.available2015-02-18T12:46:55Z-
dc.date.issued2015-
dc.identifier.citationValue in Health, 18(1): 52 - 60, (January 2015)en_US
dc.identifier.issn1098-3015-
dc.identifier.issn1524-4733-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1098301514047226-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/10265-
dc.descriptionThis article has been made available through the Brunel Open Access Publishing Fund.-
dc.description.abstractBackground Generic preference-based measures were criticized for being inappropriate in some conditions. One solution is to include "bolt-on" dimensions describing additional specific health problems. Objectives This study aimed to develop bolt-on dimensions to the EuroQol five-dimensional questionnaire (EQ-5D) and assess their impact on health state values. Methods Bolt-on dimensions were developed for vision problems, hearing problems, and tiredness. Each bolt-on dimension had three severity levels to match the EQ-5D. Three "core" EQ-5D states across a range of severity were selected, and each level of a bolt-on item was added, resulting in nine states in each condition. Health states with and without the bolt-on dimensions were valued by 300 members of the UK general public using time trade-off in face-to-face interviews, and mean health state values were compared using t tests. Regression analysis examined the impact of the bolt-on variants and the level of the bolt-on items after controlling for sociodemographic characteristics. Results Bolt-on dimensions had an impact on health state values of the EQ-5D; however, the size, direction, and significance of the impact depend on the severity of the core EQ-5D state and of the bolt-on dimension. Regression analysis demonstrated that after controlling for possible differences in sociodemographic characteristics between the groups, there were no significant differences in health state values between the three bolt-on dimensions but confirmed that the impact depended on the severity of the EQ-5D health state and the levels of bolt-on dimensions. Conclusions The impact of a bolt-on dimension on the EQ-5D depends on the core health state and the level of the bolt-on dimension. Further research in this area is encouraged.en_US
dc.description.sponsorshipThis study forms part of the NICEQoL project to investigate the use of generic and condition-specific measures of health within the NICE decision-making process. The NICEQoL project was funded by the Medical Research Council-National Institute for Health Research Methodology Research programme (reference no. G0901486). Yaling Yang was funded by the NIHR Oxford Biomedical Research Centre during the final preparation of the manuscript. Open Access funded by Medical Research Councilen_US
dc.format.extent52 - 60-
dc.format.extent52 - 60-
dc.languageeng-
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.subjectBolt-onen_US
dc.subjectEQ-5Den_US
dc.subjectHealth state valuationen_US
dc.subjectHearingen_US
dc.subjectTirednessen_US
dc.subjectvisionen_US
dc.titleAn exploratory study to test the impact on three "bolt-On" items to the EQ-5Den_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.jval.2014.09.004-
dc.relation.isPartOfValue in Health-
dc.relation.isPartOfValue in Health-
pubs.issue1-
pubs.issue1-
pubs.volume18-
pubs.volume18-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies-
pubs.organisational-data/Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Health Economics-
pubs.organisational-data/Brunel/Specialist Centres-
pubs.organisational-data/Brunel/Specialist Centres/HERG-
Appears in Collections:Brunel OA Publishing Fund
Health Economics Research Group (HERG)

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