Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9917
Title: Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects
Authors: Haverkamp, HC
Dempsey, JA
Miller, JD
Romer, LM
Pegelow, DF
Lovering, AT
Eldridge, MW
Keywords: Exercise-induced bronchospasm;Pulmonary resistance;Airway inflammation;Bronchodilation;Alveolar-to-arterial oxygen difference
Issue Date: 2005
Publisher: Journal of applied physiology
Citation: Journal of Applied Physiology, 99:5, pp. 1843 - 1852, 2005
Abstract: Twenty-one subjects with asthma underwent treadmill exercise to exhaustion at a workload that elicited approximately 90% of each subject's maximal O2 uptake (EX1). After EX1, 12 subjects experienced significant exercise-induced bronchospasm [(EIB+), %decrease in forced expiratory volume in 1.0 s = -24.0 +/- 11.5%; pulmonary resistance at rest vs. postexercise = 3.2 +/- 1.5 vs. 8.1 +/- 4.5 cmH2O.l(-1).s(-1)] and nine did not (EIB-). The alveolar-to-arterial Po2 difference (A-aDo2) was widened from rest (9.1 +/- 6.7 Torr) to 23.1 +/- 10.4 and 18.1 +/- 9.1 Torr at 35 min after EX1 in subjects with and without EIB, respectively (P < 0.05). Arterial Po2 (PaO2) was reduced in both groups during recovery (EIB+, -16.0 +/- -13.0 Torr vs. baseline; EIB-, -11.0 +/- 9.4 Torr vs. baseline, P < or = 0.05). Forty minutes after EX1, a second exercise bout was completed at maximal O2 uptake. During the second exercise bout, pulmonary resistance decreased to baseline levels in the EIB+ group and the A-aDo2 and PaO2 returned to match the values seen during EX1 in both groups. Sputum histamine (34.6 +/- 25.9 vs. 61.2 +/- 42.0 ng/ml, pre- vs. postexercise) and urinary 9alpha,11beta-prostaglandin F2 (74.5 +/- 38.6 vs. 164.6 +/- 84.2 ng/mmol creatinine, pre- vs. postexercise) were increased after exercise only in the EIB+ group (P < 0.05), and postexercise sputum histamine was significantly correlated with the exercise PaO2 and A-aDo2 in the EIB+ subjects. Thus exercise causes gas-exchange impairment during the postexercise period in asthmatic subjects independent of decreases in forced expiratory flow rates after the exercise; however, a subsequent exercise bout normalizes this impairment secondary in part to a fast acting, robust exercise-induced bronchodilatory response.
URI: http://jap.physiology.org/content/99/5/1843
http://bura.brunel.ac.uk/handle/2438/9917
DOI: http://dx.doi.org/10.1152/japplphysiol.01399.2004
ISSN: 1522-1601
Appears in Collections:Sport
Dept of Life Sciences Research Papers

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