Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/9461
Title: Optical coherence tomography measurements of biological fluid flows with picolitre spatial localization
Authors: Matcher, SJ
Byers, R
4th Micro and Nano Flows Conference (MNF2014)
Keywords: Microcirculation;Optical coherence tomography;Speckle;Phase-sensitive interferometry;Rheology
Issue Date: 2014
Publisher: Brunel University London
Citation: 4th Micro and Nano Flows Conference, University College London, UK, 7-10 September 2014, Editors CS König, TG Karayiannis and S. Balabani
Series/Report no.: ID 227
Abstract: Interest in studying the human and animal microcirculation has burgeoned in recent years. In part this has been driven by recent advances in volumetric microscopy modalities, which allow the study of the 3-D morphology of the microcirculation without the limitations of 2-D intra-vital microscopy. In this paper we highlight the power of optical coherence tomography (OCT) to image the normal and pathological microcirculation with picolitre voxel sizes. Both Doppler and speckle-variance methods are employed to characterize complex rheological flows both in-vitro and in-vivo. GPU accelerated image registration methods are demonstrated in order to mitigate problems of bulk tissue motion in methods based on speckle decorrelation. In-vivo images of the human nailfold microcirculation are shown.
Description: This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.
URI: http://bura.brunel.ac.uk/handle/2438/9461
ISBN: 978-1-908549-16-7
Appears in Collections:Brunel Institute for Bioengineering (BIB)
The Brunel Collection

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