Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/8053
Title: Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens
Authors: Orton, F
Rosivatz, E
Scholze, M
Kortenkamp, A
Keywords: Antiandrogen;AR-Lux;Biomonitoring;Endocrine disruption;Fungicide
Issue Date: 2011
Publisher: National Institute of Environmental Health Sciences
Citation: Environmental Health Perspectives, 119(6), 794 - 800, 2011
Abstract: Background: Evidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pes¬ticide exposure and data on endocrine disruption, with most of the published literature focused on pesticides that are no longer registered for use in developed countries. Objective: We used estimated human exposure data to select pesticides to test for antiandrogenic activity, focusing on highest use pesticides. Methods: We used European databases to select 134 candidate pesticides based on highest expo-sure, followed by a filtering step according to known or predicted receptor-mediated antiandrogenic potency, based on a previously published quantitative structure–activity relationship (QSAR) model. In total, 37 pesticides were tested for in vitro androgen receptor (AR) antagonism. Of these, 14 were previously reported to be AR antagonists (“active”), 4 were predicted AR antagonists using the QSAR, 6 were predicted to not be AR antagonists (“inactive”), and 13 had unknown activity, which were “out of domain” and therefore could not be classified with the QSAR (“unknown”). Results: All 14 pesticides with previous evidence of AR antagonism were confirmed as antiandrogenic in our assay, and 9 previously untested pesticides were identified as antiandrogenic (dimethomorph, fenhexamid, quinoxyfen, cyprodinil, λ-cyhalothrin, pyrimethanil, fludioxonil, azinphos-methyl, pirimiphos-methyl). In addition, we classified 7 compounds as androgenic. Conclusions: Due to estimated antiandrogenic potency, current use, estimated exposure, and lack of previous data, we strongly recommend that dimethomorph, fludioxonil, fenhexamid, imazalil, ortho-phenylphenol, and pirimiphos-methyl be tested for antiandrogenic effects in vivo. The lack of human biomonitoring data for environmentally relevant pesticides presents a barrier to current risk assessment of pesticides on humans.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114813/
http://bura.brunel.ac.uk/handle/2438/8053
DOI: http://dx.doi.org/10.1289/ehp.1002895
ISSN: 0091-6765
Appears in Collections:Biological Sciences
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