Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/14660
Title: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Authors: Speliotes, EK
Willer, CJ
Berndt, SI
Monda, KL
Thorleifsson, G
Jackson, AU
Allen, HL
Lindgren, CM
Luan, J
Maegi, R
Randall, JC
Busonero, F
Campbell, H
Cappuccio, FP
Cavalcanti-Proenca, C
Chen, Y-DI
Chen, C-M
Chines, PS
Clarke, R
Coin, L
Connell, J
Vedantam, S
Day, INM
den Heijer, M
Duan, J
Ebrahim, S
Elliott, P
Elosua, R
Eiriksdottir, G
Erdos, MR
Eriksson, JG
Facheris, MF
Winkler, TW
Felix, SB
Fischer-Posovszky, P
Folsom, AR
Friedrich, N
Freimer, NB
Fu, M
Gaget, S
Gejman, PV
Geus, EJC
Gieger, C
Qi, L
Gjesing, AP
Goel, A
Goyette, P
Grallert, H
Graessler, J
Greenawalt, DM
Groves, CJ
Gudnason, V
Guiducci, C
Hartikainen, A-L
Workalemahu, T
Hassanali, N
Hall, AS
Havulinna, AS
Hayward, C
Heath, AC
Hengstenberg, C
Hicks, AA
Hinney, A
Hofman, A
Homuth, G
Heid, IM
Hui, J
Igl, W
Iribarren, C
Isomaa, B
Jacobs, KB
Jarick, I
Jewell, E
John, U
Jorgensen, T
Jousilahti, P
Steinthorsdottir, V
Jula, A
Kaakinen, M
Kajantie, E
Kaplan, LM
Kathiresan, S
Kettunen, J
Kinnunen, L
Knowles, JW
Kolcic, I
Koenig, IR
Stringham, HM
Koskinen, S
Kovacs, P
Kuusisto, J
Kraft, P
Kvaloy, K
Laitinen, J
Lantieri, O
Lanzani, C
Launer, LJ
Lecoeur, C
Weedon, MN
Lehtimaeki, T
Lettre, G
Liu, J
Lokki, M-L
Lorentzon, M
Luben, RN
Ludwig, B
Manunta, P
Marek, D
Marre, M
Wheeler, E
Martin, NG
McArdle, WL
McCarthy, A
McKnight, B
Meitinger, T
Melander, O
Meyre, D
Midthjell, K
Montgomery, GW
Morken, MA
Wood, AR
Morris, AP
Mulic, R
Ngwa, JS
Nelis, M
Neville, MJ
Nyholt, DR
O'Donnell, CJ
O'Rahilly, S
Ong, KK
Oostra, B
Ferreira, T
Pare, G
Parker, AN
Perola, M
Pichler, I
Pietilaeinen, KH
Platou, CGP
Polasek, O
Pouta, A
Rafelt, S
Raitakari, O
Weyant, RJ
Rayner, NW
Ridderstrale, M
Rief, W
Ruokonen, A
Robertson, NR
Rzehak, P
Salomaa, V
Sanders, AR
Sandhu, MS
Sanna, S
Segre, AV
Saramies, J
Savolainen, MJ
Scherag, S
Schipf, S
Schreiber, S
Schunkert, H
Silander, K
Sinisalo, J
Siscovick, DS
Smit, JH
Estrada, K
Soranzo, N
Sovio, U
Stephens, J
Surakka, I
Swift, AJ
Tammesoo, M-L
Tardif, J-C
Teder-Laving, M
Teslovich, TM
Thompson, JR
Liang, L
Thomson, B
Toenjes, A
Tuomi, T
van Meurs, JBJ
van Ommen, G-J
Vatin, V
Viikari, J
Visvikis-Siest, S
Vitart, V
Vogel, CIG
Nemesh, J
Voight, BF
Waite, LL
Wallaschofski, H
Walters, GB
Widen, E
Wiegand, S
Wild, SH
Willemsen, G
Witte, DR
Witteman, JC
Park, J-H
Xu, J
Zhang, Q
Zgaga, L
Ziegler, A
Zitting, P
Beilby, JP
Farooqi, IS
Hebebrand, J
Huikuri, HV
James, AL
Gustafsson, S
Kaehoenen, M
Levinson, DF
Macciardi, F
Nieminen, MS
Ohlsson, C
Palmer, LJ
Ridker, PM
Stumvoll, M
Beckmann, JS
Boeing, H
Kilpelaenen, TO
Boerwinkle, E
Boomsma, DI
Caulfield, MJ
Chanock, SJ
Collins, FS
Cupples, LA
Smith, GD
Erdmann, J
Froguel, P
Greonberg, H
Yang, J
Gyllensten, U
Hall, P
Hansen, T
Harris, TB
Hattersley, AT
Hayes, RB
Heinrich, J
Hu, FB
Hveem, K
Illig, T
Bouatia-Naji, N
Jarvelin, M-R
Kaprio, J
Karpe, F
Khaw, K-T
Kiemeney, LA
Krude, H
Laakso, M
Lawlor, DA
Metspalu, A
Munroe, PB
Esko, T
Ouwehand, WH
Pedersen, O
Penninx, BW
Peters, A
Pramstaller, PP
Quertermous, T
Reinehr, T
Rissanen, A
Rudan, I
Samani, NJ
Feitosa, MF
Schwarz, PEH
Shuldiner, AR
Spector, TD
Tuomilehto, J
Uda, M
Uitterlinden, A
Valle, TT
Wabitsch, M
Waeber, G
Wareham, NJ
Kutalik, Z
Watkins, H
Wilson, JF
Wright, AF
Zillikens, MC
Chatterjee, N
McCarroll, SA
Purcell, S
Schadt, EE
Visscher, PM
Assimes, TL
Mangino, M
Borecki, IB
Deloukas, P
Fox, CS
Groop, LC
Haritunians, T
Hunter, DJ
Kaplan, RC
Mohlke, KL
O'Connell, JR
Peltonen, L
Raychaudhuri, S
Schlessinger, D
Strachan, DP
van Duijn, CM
Wichmann, H-E
Frayling, TM
Thorsteinsdottir, U
Abecasis, GR
Barroso, I
Boehnke, M
Stefansson, K
Scherag, A
North, KE
McCarthy, MI
Hirschhorn, JN
Ingelsson, E
Loos, RJF
Smith, AV
Welch, R
Zhao, JH
Aben, KK
Absher, DM
Amin, N
Dixon, AL
Fisher, E
Glazer, NL
Goddard, ME
Heard-Costa, NL
Hoesel, V
Hottenga, J-J
Johansson, A
Johnson, T
Ketkar, S
Lamina, C
Li, S
Moffatt, MF
Myers, RH
Narisu, N
Perry, JRB
Peters, MJ
Preuss, M
Ripatti, S
Rivadeneira, F
Sandholt, C
Scott, LJ
Timpson, NJ
Tyrer, JP
van Wingerden, S
Watanabe, RM
White, CC
Wiklund, F
Barlassina, C
Chasman, DI
Cooper, MN
Jansson, J-O
Lawrence, RW
Pellikka, N
Prokopenko, I
Shi, J
Thiering, E
Alavere, H
Alibrandi, MTS
Almgren, P
Arnold, AM
Aspelund, T
Atwood, LD
Balkau, B
Balmforth, AJ
Bennett, AJ
Ben-Shlomo, Y
Bergman, RN
Bergmann, S
Biebermann, H
Blakemore, AIF
Boes, T
Bonnycastle, LL
Bornstein, SR
Brown, MJ
Buchanan, TA
Keywords: Science & Technology;Life Sciences & Biomedicine;Genetics & Heredity;GENETICS & HEREDITY;GENOME-WIDE ASSOCIATION;GASTRIC-INHIBITORY POLYPEPTIDE;MELANOCORTIN-4 RECEPTOR GENE;GLUCOSE-HOMEOSTASIS;COMMON VARIANTS;ADULT OBESITY;EARLY-ONSET;FTO GENE;FAT MASS;RISK
Issue Date: 2010
Publisher: Nature Publishing Group
Citation: NATURE GENETICS, 42 (11): pp. 937 - U53 (14), (2010)
Abstract: Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity-susceptibility loci and identified 18 new loci associated with BMI (P<5×10−8), one of which includes a copy number variant near GPRC5B. Some loci (MC4R, POMC, SH2B1, BDNF) map near key hypothalamic regulators of energy balance, and one is near GIPR, an incretin receptor. Furthermore, genes in other newly-associated loci may provide novel insights into human body weight regulation.
URI: http://bura.brunel.ac.uk/handle/2438/14660
DOI: http://dx.doi.org/10.1038/ng.686
ISSN: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
1061-4036
Appears in Collections:Dept of Life Sciences Research Papers

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