Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/14657
Title: Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci
Authors: Buxton, JL
Suderman, M
Pappas, JJ
Borghol, N
McArdle, W
Blakemore, AIF
Hertzman, C
Power, C
Szyf, M
Pembrey, M
Keywords: Science & Technology;Multidisciplinary Sciences;Science & Technology - Other Topics;MULTIDISCIPLINARY SCIENCES;OXIDATIVE STRESS;SHORTENS TELOMERES;DISEASE;POSITION;CELLS;DYSFUNCTION;SENESCENCE;VIABILITY;INSIGHTS;TISSUES
Issue Date: 2014
Publisher: Nature Publishing Group
Citation: SCIENTIFIC REPORTS, (2014)
Abstract: In humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL is associated with increased risk of age-related disease. In this study we tested for association between telomere length and methylated cytosine levels. Measurements of mean telomere length and DNA methylation at .450,000 CpG sites were obtained for both blood (N 5 24) and EBV-transformed cell-line (N 5 36) DNA samples from men aged 44–45 years. We identified 65 gene promoters enriched for CpG sites at which methylation levels are associated with leukocyte telomere length, and 36 gene promoters enriched for CpG sites at which methylation levels are associated with telomere length in DNA from EBV-transformed cell-lines.Weobserved significant enrichment of positively associated methylated CpG sites in subtelomeric loci (within 4 Mb of the telomere) (P , 0.01), and also at loci in imprinted regions (P , 0.001). Our results pave the way for further investigations to help elucidate the relationships between telomere length, DNA methylation and gene expression in health and disease.
URI: http://bura.brunel.ac.uk/handle/2438/14657
DOI: http://dx.doi.org/10.1038/srep04954
ISSN: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335812200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
ARTN 4954
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335812200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5
ARTN 4954
2045-2322
Appears in Collections:Dept of Life Sciences Research Papers

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