Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/14627
Title: Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Authors: Surendran, P
Drenos, F
Young, R
Warren, H
Cook, JP
Manning, AK
Grarup, N
Sim, X
Barnes, DR
Witkowska, K
Staley, JR
Kuusisto, J
Laakso, M
Padmanabhan, S
Porteous, DJ
Hayward, C
Scotland, G
Collins, FS
Mohlke, KL
Hansen, T
Harakalova, M
Rauramaa, R
Pedersen, O
Boehnke, M
Stringham, HM
Frossard, P
Newton-Cheh, C
Tobin, MD
Nordestgaard, BG
Caulfield, MJ
Mahajan, A
Morris, AP
Polasek, O
Mihailov, E
Tomaszewski, M
Samani, NJ
Saleheen, D
Asselbergs, FW
Lindgren, CM
Danesh, J
Wain, LV
Butterworth, AS
Howson, JMM
Rudan, I
Munroe, PB
Liu, C
Kraja, AT
Nielsen, SF
Rasheed, A
Samue, M
Zhao, W
Bonnycastle, LL
Jackson, AU
Narisu, N
Rolandsson, O
Swift, AJ
Southam, L
Marten, J
Huyghe, JR
Stancakova, A
Fava, C
Ohlsson, T
Matchan, A
Stirrups, KE
Bork-Jensen, J
Franks, PW
Gjesing, AP
Kontto, J
Perola, M
Shaw-Hawkins, S
Havulinna, AS
Zhang, H
Donnelly, LA
Groves, CJ
Rayner, NW
Neville, MJ
Dedoussis, G
Robertson, NR
Yiorkas, AM
Herzig, K-H
Kajantie, E
Zhang, W
Willems, SM
Lannfelt, L
Malerba, G
Soranzo, N
Trabetti, E
Spector, TD
Verweij, N
Evangelou, E
Moayyeri, A
Vergnaud, A-C
Nelson, CP
Poveda, A
Varga, TV
Caslake, M
de Craen, AJM
Trompet, S
Jousilahti, P
Luan, J
Scott, RA
Harris, SE
Liewald, DCM
Marioni, R
Menni, C
Farmaki, A-E
Hallmans, G
Renstrom, F
Huffman, JE
Mannisto, S
Hassinen, M
Burgess, S
Vasan, RS
Felix, JF
Uria-Nickelsen, M
Malarstign, A
Reilly, DF
Hoek, M
Vogt, TF
Lin, H
Deary, IJ
Lieb, W
Traylor, M
Markus, HS
Highland, HM
Justice, AE
Marouli, E
Lindstrom, J
Uusitupa, M
Komulainen, P
Lakka, TA
Tragante, V
Starr, JM
Langenberg, C
Wareham, NJ
Brown, MJ
Dominiczak, AF
Connell, JM
Jukema, JW
Sattar, N
Ford, I
Packard, CJ
Tukiainen, T
Esko, T
Magi, R
Metspalu, A
de Boer, RA
van der Meer, P
van der Harst, P
Gambaro, G
Ingelsson, E
Lind, L
de Bakker, PIW
Yaghootkar, H
Numans, ME
Brandslund, I
Christensen, C
Petersen, ERB
Korpi-Hyovalti, E
Oksa, H
Chambers, JC
Kooner, JS
Blakemore, AIF
Franks, S
Masca, N
Jarvelin, M-R
Husemoen, LL
Linneberg, A
Skaaby, T
Thuesen, B
Karpe, F
Tuomilehto, J
Doney, ASF
Morris, AD
Palmer, CNA
Freitag, DF
Holmen, OL
Hveem, K
Willer, CJ
Tuomi, T
Groop, L
Karajamaki, A
Palotie, A
Ripatti, S
Salomaa, V
Alam, DS
Ferreira, T
Majmnder, AAS
Di Angelantonio, E
Chowdhury, R
McCarthy, MI
Poulter, N
Stanton, AV
Sever, P
Amouyel, P
Arveiler, D
Blankenberg, S
Giannakopoulou, O
Ferrieres, J
Kee, F
Kuulasmaa, K
Muller-Nurasyid, M
Veronesi, G
Virtamo, J
Deloukas, P
Elliott, P
Zeggini, E
Kathiresan, S
Tinker, A
Melander, O
Keywords: Genome-wide association studies;Hypertension;Population genetics
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Nature Genetics, 48(10): pp. 1151 - 1161, (2016)
Abstract: High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ~155,063 samples for independent replication. We identified 30 new blood pressure– or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
URI: http://bura.brunel.ac.uk/handle/2438/14627
DOI: http://dx.doi.org/10.1038/ng.3654
ISSN: 1061-4036
Appears in Collections:Dept of Life Sciences Research Papers

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