Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10770
Title: Chemical models important in understanding the ways in which chromate can damage DNA
Authors: OBRIEN, P
KORTENKAMP, A
Keywords: Science & Technology;Life Sciences & Biomedicine;Environmental Sciences;Public, Environmental & Occupational Health;Toxicology;Environmental Sciences & Ecology;Chromium (VI);Chromium (V);Glutathione;Ascorbic Acid;Electron Spin-Tripping;Resonance Spin-Tripping;DNA Strand breaks;Competition Kinetics;Hydrogen-Peroxide;Ascorbic-Acid;Hexavalent Chromium;Carcinogen Chromate;Spin-Trap;Reduction;Mechanism;Generation
Issue Date: 1994
Publisher: National Institutes of Health
Citation: Environmental Health Perspect. 1994 Sep; 102(Suppl 3): 3–10.
Abstract: Chromate is an established human carcinogen. There have been many studies of the reactivity of chromate aimed at improving understanding of chromate toxicity. In the present paper a number of conclusions of these studies are reviewed and considered in the light of new results obtained in our laboratories. A number of hypotheses are considered; it is concluded, however, that it is impossible to reconcile the generation of strand breaks by chromate during its reduction by glutathione with any simple mechanism involving the generation of DNA lesions by free hydroxyl radicals. Kinetic, spin-trapping, and competition kinetic studies, based on a strand-breaking assay, are reported in support of this conclusion.
URI: http://bura.brunel.ac.uk/handle/2438/10770
DOI: http://dx.doi.org/10.2307/3431753
ISSN: 0091-6765
Appears in Collections:Environment

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