Please use this identifier to cite or link to this item: http://buratest.brunel.ac.uk/handle/2438/10120
Title: Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans
Authors: Lovering, AT
Romer, LM
Haverkamp, HC
Pegelow, DF
Hokanson, JS
Eldridge, MW
Keywords: alveolar-to-arterial oxygen tension difference;contrast echocardiography;pulmonary circulation;exercise-induced arterial hypoxemia;INDUCED ARTERIAL HYPOXEMIA;CONTRAST ECHOCARDIOGRAPHY;WHOLE BLOOD;ARTERIOVENOUS-MALFORMATIONS;HEMODYNAMIC-RESPONSE;ULTRASONIC CONTRAST;ALTITUDE;BUBBLES;LUNGS;PLASMA
Issue Date: 2008
Citation: Journal of Applied Physiology, 104:5, pp. 1418 - 1425, 2008
Abstract: Exercise-induced intrapulmonary arteriovenous shunting, as detected by saline contrast echocardiography, has been demonstrated in healthy humans. We have previously suggested that increases in both pulmonary pressures and blood flow associated with exercise are responsible for opening these intrapulmonary arteriovenous pathways. In the present study, we hypothesized that, although cardiac output and pulmonary pressures would be higher in hypoxia, the potent pulmonary vasoconstrictor effect of hypoxia would actually attenuate exercise-induced intrapulmonary shunting. Using saline contrast echocardiography, we examined nine healthy men during incremental (65W + 30 W/2 min) cycle exercise to exhaustion in normoxia and hypoxia (fraction of inspired O-2 = 0.12). Contrast injections were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously. At rest, no subject demonstrated intrapulmonary shunting in normoxia [ arterial P-O2 (Pa-O2) = 98 +/- 10 Torr], whereas in hypoxia (Pa-O2 = 47 +/- 5 Torr), intrapulmonary shunting developed in 3/9 subjects. During exercise, similar to 90% (8/9) of the subjects shunted during normoxia, whereas all subjects shunted during hypoxia. Four of the nine subjects shunted at a lower workload in hypoxia. Furthermore, all subjects continued to shunt at 3 min, and five subjects shunted at 5 min postexercise in hypoxia. Hypoxia has acute effects by inducing intrapulmonary arteriovenous shunt pathways at rest and during exercise and has longterm effects by maintaining patency of these vessels during recovery. Whether oxygen tension specifically regulates these novel pathways or opens them indirectly via effects on the conventional pulmonary vasculature remains unclear.
URI: http://jap.physiology.org/content/104/5/1418
http://bura.brunel.ac.uk/handle/2438/10120
DOI: http://dx.doi.org/10.1152/japplphysiol.00208.2007
metadata.dc.relation.replaces: http://bura.brunel.ac.uk/handle/2438/9909
2438/9909
ISSN: 8750-7587
Appears in Collections:Sport
Dept of Life Sciences Research Papers

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